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产品信息
H00026508-M02
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2b, kappa
分类
Monoclonal
类型
Antibody
克隆号
4A11
抗原
HEYL (NP_055386, 221 a.a. approximately 327 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Cell lysate).
Immunogen sequence: PLRRATGIIL PARRNVLPSR GASSTRRARP LERPATPVPV APSSRAARSS HIAPLLQSSS PTPPGPTGSA AYVAVPTPNS SSPGPAGRPA GAMLYHSWVS EITEIGA
靶标信息
This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The sequence of the encoded protein contains a conserved bHLH and orange domain, but its YRPW motif has diverged from other HESR family members. It is thought to be an effector of Notch signaling and a regulator of cell fate decisions. Alternatively spliced transcript variants have been found, but their biological validity has not been determined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: bHLHb33; Class B basic helix-loop-helix protein 33; Hairy-related transcription factor 3; hairy/enhancer-of-split related with YRPW motif 3; Hairy/enhancer-of-split related with YRPW motif-like protein; hes-related family bHLH transcription factor with YRPW motif-like; HEY-like protein; hHeyL; hHRT3; HRT-3
基因别名: BHLHB33; HESR3; HEY3; HEYL; HRT3
UniProt ID: (Human) Q9NQ87
Entrez Gene ID: (Human) 26508
RNA polymerase II core promoter sequence-specific DNA binding
transcription factor activity, RNA polymerase II core promoter sequence-specific
transcription factor activity, protein binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II transcription corepressor activity
transcription factor activity, sequence-specific DNA binding
transcription corepressor activity
protein binding
transcription factor binding
microsatellite binding
protein homodimerization activity
protein heterodimerization activity
AF-1 domain binding
basic helix-loop-helix transcription factor
negative regulation of transcription from RNA polymerase II promoter
outflow tract morphogenesis
atrioventricular valve morphogenesis
pulmonary valve morphogenesis
epithelial to mesenchymal transition involved in endocardial cushion formation
endocardial cushion morphogenesis
cardiac ventricle morphogenesis
transcription from RNA polymerase II promoter
Notch signaling pathway
mesenchymal cell development
glomerulus development
skeletal muscle cell differentiation
positive regulation of neuron differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
cardiac epithelial to mesenchymal transition
ventricular septum morphogenesis
negative regulation of androgen receptor signaling pathway
cellular response to BMP stimulus
proximal tubule development
negative regulation of androgen receptor activity
