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HFE2 Antibody (PA5-121913) in IHC (P)
Immunohistochemistry of HFE2 in paraffin-embedded human kidney tissue. Samples were incubated in polyclonal HFE2 antibody (Product # PA5-121913) using a dilution of 20 µg/mL, followed by HRP-Linked Caprine Anti-Rabbit IgG at a dilution of 2 µg/mL and DAB.
产品信息
PA5-121913
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Lys234-Ser416 (Accession Q6ZVN8), with N-terminal His Tag
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2915485
靶标信息
HFE2 is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DL M; Fidgetin; haemojuvelin; HEMOCHROMATOSIS; Hemochromatosis type 2 protein; Hemojuvelin; Hemojuvelin BMP coreceptor; HFE 2; MGC23953; OTTHUMP00000059680; repulsive guidance molecule c; RGM C; RGM domain family member C
基因别名: HFE2; HFE2A; HJV; JH; RGMC
UniProt ID: (Human) Q6ZVN8
Entrez Gene ID: (Human) 148738
negative regulation of transcription from RNA polymerase II promoter
cellular iron ion homeostasis
protein autoprocessing
BMP signaling pathway
negative regulation of BMP signaling pathway
activin receptor signaling pathway
positive regulation of transcription from RNA polymerase II promoter
iron ion homeostasis
cellular response to BMP stimulus
