Invitrogen

HIF-2 alpha Polyclonal Antibody

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说明书
实验方案
技术支持

产品信息

PA5-85190

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:3,000
-

免疫细胞化学 (ICC/IF)

1:100
-

染色质免疫沉淀 实验 (ChIP)

2.5 µg/10^6 cells
-
产品规格

种属反应

Human, Zebrafish

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein encompassing a sequence within the center region of human HIF2 alpha.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7, with 20% glycerol

内含物

0.025% ProClin 300

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2792335

产品详细信息

Keep as concentrated solution.

Predicted reactivity: Mouse (97%), Rat (95%), Xenopus laevis (86%), Pig (99%), Chicken (94%), Bovine (98%).

Positive Control: HepG2 (1% O2 treatment for 24hr), HT1080, 786-0, FADU.

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

HIF-2 alpha (Epas1) is a transcription factor involved in the induction of genes regulated by oxygen. HIF-2 alpha contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. It also regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of the lungs. Mutations in this gene are associated with erythrocytosis familial type 4.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Basic-helix-loop-helix-PAS protein MOP2; bHLHe73; Class E basic helix-loop-helix protein 73; endothelial PAS domain protein 1; Endothelial PAS domain-containing protein 1; EPAS-1; HIF-1-alpha-like factor; HIF-1alpha-like factor; HIF-2-alpha; hif-2a; HIF-2alpha; HIF2-alpha; HIF2A; HLF; hypoxia inducible factor 2 alpha; hypoxia-inducible factor 2 alpha; Hypoxia-inducible factor 2-alpha; Member of PAS protein 2; PAS domain-containing protein 2

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基因别名: BHLHE73; ECYT4; EPAS1; hif-2ab; HIF2A; HLF; MOP2; PASD2; wu:fq36f01

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UniProt ID: (Human) Q99814

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Entrez Gene ID: (Human) 2034, (Zebrafish) 555192

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功能
RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding protein binding transcription factor binding histone acetyltransferase binding sequence-specific DNA binding protein heterodimerization activity transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding protein dimerization activity basic helix-loop-helix transcription factor
参与通路
angiogenesis response to hypoxia embryonic placenta development blood vessel remodeling regulation of heart rate transcription from RNA polymerase II promoter mitochondrion organization signal transduction visual perception erythrocyte differentiation lung development somatic stem cell population maintenance norepinephrine metabolic process surfactant homeostasis regulation of transcription from RNA polymerase II promoter in response to oxidative stress positive regulation of transcription from RNA polymerase II promoter cell maturation myoblast fate commitment iron ion homeostasis regulation of transcription from RNA polymerase II promoter in response to hypoxia cellular response to hypoxia regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter response to activity neuron differentiation exocrine pancreas development regulation of neuron apoptotic process digestive tract development neuron apoptotic process neuronal stem cell population maintenance embryonic liver development
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