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产品信息
PA5-58261
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.4 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2642442
产品详细信息
Immunogen sequence: RESQEQGLRQ RLLDEQFAVL RGAAAEAAGI LQDAVSKLDD PLHLRCTSSP DYLVSRAQEA LDAVSTLEEG HAQYLTSLAD ASALVAALTR FSHLAADTII NGGATSHLA
Highest antigen sequence identity to the following orthologs: Mouse - 85%, Rat - 87%.
靶标信息
Huntingtin disease, a neurodegenerate disease, is caused by the expansion of a polymorphic glutamine tract in huntingtin. The Huntingtin Interacting Protein 1 (HIP-1) is a reportedly proapoptotic, cargo-specific adaptor protein that may be involved in the pathogenesis of Huntingtin disease. As well as playing a role in Huntingtin disease, it is likely to be involved in the recruitment of clathrin coats to lipid membranes and it may also factor in tumorigenesis by allowing the survival of precancerous and cancerous cells. Since HIP-1 expression is significantly associated with prostate and colon cancer metastasis, HIP-1 can serve as a putative prognostic factor for prostate and colon cancers.
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生物信息学
蛋白别名: HIP-12; HIP1-related protein; huntingtin interacting protein 12; Huntingtin-interacting protein 1-related protein; Huntingtin-interacting protein 12
基因别名: HIP12; HIP1R; HIP3; ILWEQ; KIAA0655
UniProt ID: (Human) O75146
Entrez Gene ID: (Human) 9026
