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产品信息
PA5-65995
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2664178
产品详细信息
Immunogen sequence: KGEVTEMFSYE ESNPKDPAAV TESKEGTEAS ASKGLEKKEK
Highest antigen sequence identity to the following orthologs - mouse 88%, rat 90%.
靶标信息
Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. May play a role in graft rejection. May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein. Involved in the intramembrane cleavage of the integral membrane protein PSEN1. Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139- dependent manner.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: hIMP1; histocompatibility (minor) 13; histocompatibility 13; IMP-1; Intramembrane protease 1; minor histocompatibility antigen 13; Minor histocompatibility antigen H13; Presenilin-like protein 3; Signal peptide peptidase; signal peptide peptidase beta; signal peptide peptidase like 1
基因别名: H13; HM13; IMP1; IMPAS; IMPAS-1; MSTP086; PSENL3; PSL3; SPP; SPPL1
UniProt ID: (Human) Q9H111
Entrez Gene ID: (Human) 81502
