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HMBOX1 Antibody (PA5-115366) in ICC/IF
Immunocytochemistry analysis of HMBOX1 in HeLa cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-115366). Secondary staining was applied with mouse anti-beta tubulin (1 hr at 37°, AlexaFluor 594 conjugated goat anti-rabbit IgG (Red), AlexaFluor 488 conjugated goat anti-mouse IgG (Green) and DAPI.
产品信息
PA5-115366
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human HMBOX1(Accession Q6NT76), corresponding to amino acid residues E42-T92.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2900002
产品详细信息
Antibody detects endogenous levels of total HMBOX1.
靶标信息
HMBOX1 is located at the boundary of 8p12.3 and 8p21.1. HMBOX1 proteins are highly conserved in human, mouse, rat, chicken and Xenopus laevis. Functional HMBOX1::EGFP (enhanced green fluorescent protein) fusion protein revealed that HMBOX1 accumulated more in cytoplasm than in nucleus. HMBOX1 is a transcription repressor. Human HMBOX1 is widely expressed in 18 tissues, and it is highly expressed in pancreas. Hmbox1 is widely expressed in mouse pancreas and the expression of this gene can also be detected in pallium, hippocampus and hypothalamus.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: homeobox containing 1; Homeobox telomere-binding protein 1; Homeobox-containing protein 1; homeobox-containing protein PBHNF; Telomere-associated homeobox-containing protein 1
基因别名: AI451877; AI604847; F830020C16Rik; HMBOX1; HNF1LA; HOT1; PBHNF; RGD1306787; TAH1
UniProt ID: (Human) Q6NT76, (Mouse) Q8BJA3
Entrez Gene ID: (Human) 79618, (Rat) 305968, (Mouse) 219150
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
transcription, DNA-templated
regulation of transcription, DNA-templated
RNA-dependent DNA biosynthetic process
positive regulation of telomere maintenance via telomerase
positive regulation of chromatin binding
positive regulation of telomerase activity
