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HMGA1 Antibody (PA5-115367) in IHC (P)
Immunohistochemistry analysis of HMGA1 in mouse spleen tissue. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-115367) at a dilution of 1:100. Secondary staining was applied with HRP conjugated anti-Rabbit.
产品信息
PA5-115367
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human HMGA1(Accession P17096), corresponding to amino acid residues K62-Q107.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2900003
产品详细信息
Antibody detects endogenous levels of total HMGA1.
靶标信息
HMGA1 encodes a non-histone protein involved in many cellular processes, including regulation of inducible gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of A+T-rich regions in double-stranded DNA. It has little secondary structure in solution but assumes distinct conformations when bound to substrates such as DNA or other proteins. The encoded protein is frequently acetylated and is found in the nucleus.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: HGNC:5010; High mobility group AT-hook protein 1; High mobility group protein A1; High mobility group protein HMG-I/HMG-Y; high mobility group protein I; High mobility group protein R; high-mobility group (nonhistone chromosomal) protein isoforms I and Y; HMG-I(Y); MGC12816; MGC4242; MGC4854; nonhistone chromosomal high-mobility group protein HMG-I/HMG-Y; OTTHUMP00000016222; OTTHUMP00000016223; OTTHUMP00000016224; OTTHUMP00000039618
基因别名: AL023995; HMG-R; HMGA1; HMGA1A; Hmga1b; Hmgi; HMGIY; Hmgy
UniProt ID: (Human) P17096, (Mouse) P17095, (Rat) Q8K585
Entrez Gene ID: (Human) 3159, (Mouse) 15361, (Rat) 117062
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
DNA binding
AT DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
enzyme binding
ligand-dependent nuclear receptor transcription coactivator activity
retinoic acid receptor binding
peroxisome proliferator activated receptor binding
retinoid X receptor binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA-(apurinic or apyrimidinic site) lyase activity
5'-deoxyribose-5-phosphate lyase activity
endodeoxyribonuclease
DNA unwinding involved in DNA replication
nucleosome disassembly
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
protein complex assembly
negative regulation of cell proliferation
response to virus
negative regulation of chromatin silencing
senescence-associated heterochromatin focus assembly
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
nuclear transport
establishment of integrated proviral latency
oncogene-induced cell senescence
positive regulation of cellular senescence
DNA metabolic process
base-excision repair
spermatogenesis
nucleic acid phosphodiester bond hydrolysis
regulation of nucleic acid-templated transcription
DNA catabolic process, endonucleolytic
transcription, DNA-templated
