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产品信息
MA5-31335
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
CL0259
抗原
Recombinant protein corresponding to Human HMGCR
偶联物
形式
Liquid
浓度
0.6 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2786972
产品详细信息
Immunogen sequence: HIPAYKLETL METHERGVSI RRQLLSKKLS EPSSLQYLPY RDYNYSLVMG ACCENVIGYM PIPVGVAGPL CLDEKEFQVP MATTEGCLVA
靶标信息
3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) is a key enzyme in the mevalonate pathway, which is critical for the biosynthesis of cholesterol and other isoprenoids. HMGCR catalyzes the conversion of HMG-CoA to mevalonate, a rate-limiting step in the production of cholesterol. Due to its central role in cholesterol synthesis, HMGCR is a primary target for statin drugs, which are used to lower cholesterol levels and reduce the risk of cardiovascular disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 3-hydroxy-3-methylglutaryl CoA reductase (NADPH); 3-hydroxy-3-methylglutaryl-coenzyme A reductase; HMDH; HMG CoA reductase; HMG CoAR; HMG-CoA reductase; hydroxymethylglutaryl-CoA reductase; MGC103269
基因别名: HMGCR; LDLCQ3
UniProt ID: (Human) P04035
Entrez Gene ID: (Human) 3156
cholesterol biosynthetic process
ubiquinone metabolic process
aging
response to nutrient
isoprenoid biosynthetic process
visual learning
negative regulation of striated muscle cell apoptotic process
positive regulation of cardiac muscle cell apoptotic process
coenzyme A metabolic process
positive regulation of stress-activated MAPK cascade
negative regulation of MAP kinase activity
myoblast differentiation
response to ethanol
negative regulation of vasodilation
positive regulation of skeletal muscle tissue development
positive regulation of smooth muscle cell proliferation
protein tetramerization
oxidation-reduction process
negative regulation of wound healing
negative regulation of insulin secretion involved in cellular response to glucose stimulus
positive regulation of ERK1 and ERK2 cascade
