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HMGN1 Antibody (A302-363A) in IHC (P)
Detection of human and mouse HMGN1 by immunohistochemistry. Sample: FFPE section of human breast carcinoma (left) and mouse teratoma (right). Antibody: Affinity purified rabbit anti-HMGN1 (Product # A302-363A) (Lot 1) used at a dilution of 1:5,000 (0.2 µg/mL). Detection: DAB.
产品信息
A302-363A
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Region between residue 90 and 100 of human high-mobility group nucleosome binding domain 1.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
tris citrate/phosphate, pH 7-8
内含物
0.09% sodium azide
保存条件
4° C
运输条件
Wet ice
产品详细信息
The recommended shelf life for this product is 1 year from date of receipt.
Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
靶标信息
The high-mobility group (HMG) proteins 14 and 17 are abundant chromosomal proteins that bind to nucleosomes and enhance transcription. HMG-14 and HMG-17 also function as architectural elements, which alter the structure of the chromatin fiber and enhance transcription from chromatin templates. HMG-14/17 proteins modify the nucleosomal organization of the 30 nm chromatin fiber and mediate the unfolding of the higher order chromatin structure thereby facilitating access to the underlying DNA sequence. Clustering of architectural elements, such as HMG proteins and linker histone subtypes into distinct domains, may lead to structural and functional heterogeneity along the chromatin fiber. In addition, HMG-14 and HMG-17 have been identified as constitutive components of mouse oocyte and embryonic chromatin that establish a link between the structure of embryonic chromatin and the normal progression of embryonic development.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FLJ27265; FLJ31471; High mobility group nucleosome-binding domain-containing protein 1; high mobility group protein 14; high-mobility group (nonhistone chromosomal) protein 14; high-mobility group nucleosome binding 1; high-mobility group nucleosome binding domain 1; high-mobility group nucleosome-binding domain-containing protein 1; HMG 14; HMGN 1; MGC104230; MGC117425; Non-histone chromosomal protein HMG-14; nonhistone chromosomal protein HMG-14
基因别名: HMG-14; HMG14; HMGN1
UniProt ID: (Human) P05114, (Mouse) P18608
Entrez Gene ID: (Human) 3150, (Mouse) 15312
transcription-coupled nucleotide-excision repair
positive regulation of DNA-templated transcription, elongation
pyrimidine dimer repair by nucleotide-excision repair
chromatin organization
regulation of transcription from RNA polymerase II promoter
response to UV-B
response to UV-C
regulation of development, heterochronic
post-embryonic camera-type eye morphogenesis
regulation of epithelial cell proliferation
