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HNF1A Antibody (PA5-116983) in WB
Western blot analysis of HNF1A in extracts of various cell lines. Samples were incubated with HNF1A Polyclonal antibody (Product # PA5-116983) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.
产品信息
PA5-116983
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 30-130 of human HNF1α (NP_0005366)
偶联物
形式
Liquid
浓度
0.62 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2901613
产品详细信息
Positive Samples: 293T, LO2
Immunogen sequence: LGEPGPYLLA GEGPLDKGES CGGGRGELAE LPNGLGETRG SEDETDDDGE DFTPPILKEL ENLSPEEAAH QKAVVETLLQ EDPWRVAKMV KSYLQQHNIP Q
靶标信息
This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: albumin proximal factor; hepatic nuclear factor 1; hepatic nuclear factor-1-alpha; hepatocyte nuclear factor 1; Hepatocyte nuclear factor 1-alpha; hnf-1 alpha; HNF-1-alpha; HNF-1A; interferon production regulator factor; LF-B1 hepatic nuclear factor (HNF1): albumin proximal factor also TCF1; LF-B1, hepatic nuclear factor (HNF1): albumin proximal factor, also TCF1; LFB1; Liver-specific transcription factor LF-B1; TCF-1; Transcription factor 1; Transcription factor 1 hepatic; Transcription factor 1, hepatic
基因别名: AI323641; Hnf-1; HNF-1A; HNF1; HNF1-alpha; HNF1[a]; HNF1A; Hnf1alpha; IDDM20; LF-B1; LFB1; MODY3; TCF-1; TCF1
UniProt ID: (Human) P20823, (Rat) P15257, (Mouse) P22361
Entrez Gene ID: (Human) 6927, (Rat) 24817, (Mouse) 21405
RNA polymerase II regulatory region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription regulatory region DNA binding
protein dimerization activity
RNA polymerase II core promoter sequence-specific DNA binding
transcription cofactor binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
double-stranded DNA binding
transcription factor binding
protein homodimerization activity
sequence-specific DNA binding
protein heterodimerization activity
DNA-binding transcription factor
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
regulation of pronephros size
renal glucose absorption
glucose homeostasis
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
glucose import
positive regulation of transcription initiation from RNA polymerase II promoter
negative regulation of transcription from RNA polymerase II promoter
blastocyst development
liver development
placenta development
chromatin remodeling
regulation of transcription, DNA-templated
fatty acid biosynthetic process
bile acid biosynthetic process
heme biosynthetic process
response to oxidative stress
protein localization
cholesterol metabolic process
response to glucose
bile acid and bile salt transport
fatty acid transport
insulin secretion
regulation of Wnt signaling pathway
embryonic limb morphogenesis
endocrine pancreas development
reverse cholesterol transport
bone resorption
regulation of hormone secretion
paraxial mesoderm formation
reproductive structure development
regulation of insulin secretion
SMAD protein signal transduction
transcription, DNA-templated
