Invitrogen

HOMER1 Polyclonal Antibody

HOMER1 Antibody in Immunocytochemistry (ICC/IF)

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HOMER1 Antibody (PA5-21487) in ICC/IF

Immunofluorescence analysis of HOMER1 was performed using 90% confluent log phase PC-12 cells differentiated to Neuronal cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 1% BSA for 1 hour at room temperature. The cells were labeled with HOMER1 Rabbit Polyclonal Antibody (Product # PA5-21487) at 5 microgram/mL in 0.1% BSA, incubated at 4 degree Celsius overnight and then labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, ... View More

HOMER1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

HOMER1 Antibody in Immunohistochemistry (Frozen) (IHC (F))

HOMER1 Antibody in Immunoprecipitation (IP)

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产品信息

PA5-21487

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:10,000

免疫组化 (IHC)

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免疫组化（石蜡） (IHC (P))

1:100-1:1,000

免疫组化（冰冻） (IHC (F))

1:100-1:1,000

免疫细胞化学 (ICC/IF)

1:100-1:1,000

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免疫沉淀 (IP)

1:100-1:500

产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant fragment corresponding to a region within amino acids 72 and 339 of Homer (Uniprot ID#Q86YM7)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.12 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7, with 20% glycerol

内含物

0.025% ProClin 300

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_11155843

产品详细信息

Recommended positive controls: U87-MG, SK-N-SH, IMR32, SK-N-AS, mouse brain, rat brain.

Predicted reactivity: Mouse (97%), Rat (91%), Xenopus laevis (85%), Pig (98%), Rhesus Monkey (99%), Bovine (97%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

HOMER1 is a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Inhibition of unfolded protein response prevents post-anesthesia neuronal hyperactivity and synapse loss in aged mice.

Aging cell

Chen K,Hu Q,Gupta R,Stephens J,Xie Z,Yang G

PA5-21487 was used in Immunohistochemistry-immunofluorescence to suggest that sevoflurane anesthesia causes abnormal UPR in the aged brain, which contributes to neuronal hyperactivity, synapse loss and cognitive decline in aged mice.

Fri Apr 01 00:00:00 UTC 2022

Human neurexin-3α antibodies associate with encephalitis and alter synapse development.

Neurology

Gresa-Arribas N,Planagumà J,Petit-Pedrol M,Kawachi I,Katada S,Glaser CA,Simabukuro MM,Armangué T,Martínez-Hernández E,Graus F,Dalmau J

PA521487 was used in immunocytochemistry to characterize a novel autoimmune encephalitis

Tue Jun 14 00:00:00 UTC 2016

生物信息学

蛋白别名: homer homolog 1; Homer protein homolog 1; homer, neuronal immediate early gene, 1; Homer-1; immediate early gene protein Homer1A; PSD-Zip45; scaffold protein; VASP/Ena-related gene up-regulated during seizure and LTP 1; Vesl-1

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基因别名: HOMER; homer-1; HOMER1; HOMER1A; HOMER1B; HOMER1C; HOMER1F; PSD-Zip45; SYN47; Ves-1; Vesl; Vesl-1; Vesl1

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UniProt ID: (Human) Q86YM7, (Mouse) Q9Z2Y3, (Rat) Q9Z214

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Entrez Gene ID: (Human) 9456, (Mouse) 26556, (Rat) 29546

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功能