Invitrogen

HOXA11/HOXD11 Polyclonal Antibody

HOXA11/HOXD11 Antibody in Western Blot (WB)

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HOXA11/HOXD11 Antibody (PA5-101637) in WB

Western blot analysis of HOXA11/HOXD11 in RAW264.7 cells. Samples were incubated with HOXA11/HOXD11 polyclonal antibody (Product # PA5-101637).

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产品信息

PA5-101637

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

免疫细胞化学 (ICC/IF)

1:100-1:500

产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthesized peptide derived from human HOXA11(Accession P31270), corresponding to amino acid residues P137-P187.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

AB_2851071

产品详细信息

Antibody detects endogenous levels of total HOXA11/D11.

靶标信息

HOX11, also called homeobox11 or Tcl-3 is located at the 10q24 T-Cell translocation breakpoint region. It encodes a homeobox-domain containing protein, HOX11, containing a glycine and proline-rich amino terminus. HOX11 is required for maintenance of the developing spleen and cell survival. The HOX11protein binds to a specific DNA sequence and localizes to the cell nucleus. It transactivates transcription of a reporter gene linked to a cis-regulatory element, acting as a positive transcription activator. The HOX11 gene is highly expressed in T-ALLs as a result of a t (7:10) (q35;q24) or t(10:14)(q24;qll) translocation. The homeobox gene is deregulated upon translocation into the T-cell receptor locus and activates a specific subset of tumor-associated target genes. HOX 11 gene translocation has been attributed to T-cell leukemia and lymphoid neoplasias.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: homeo box 1I; homeo box 4F; homeo box A11; homeo box D11; Homeobox protein Hox-1.9; Homeobox protein Hox-1I; Homeobox protein Hox-4.6; Homeobox protein Hox-4F; Homeobox protein Hox-5.5; Homeobox protein Hox-A11; Homeobox protein Hox-D11; homeobox protein HOXA11; Hox-4.6, mouse, homolog of; HOX11

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基因别名: E230017H14Rik; Hox-1.9; Hox-4.6; Hox-5.4; Hox-5.5; HOX1; HOX1I; HOX4; HOX4F; Hoxa-11; HOXA11; Hoxd-11; HOXD11; RUSAT1