Invitrogen

HOXA13 Polyclonal Antibody

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HOXA13 Antibody (PA5-76440) in WB

Western blot analysis of HOXA13 in extracts of various cells. Samples were incubated with HOXA13 polyclonal antibody (Product # PA5-76440).

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产品信息

PA5-76440

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000-1:4,000

免疫组化 (IHC)

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其他PubMed (Misc)

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产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant fusion protein of human HOXA13.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 50% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2720167

产品详细信息

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

靶标信息

HoxA13 and HoxD13 also bind to other BMP and TGF-beta/Activin-regulated Smad proteins including Smad1 and Smad2, but not Smad4. In humans and mice, loss of HOXA13 function causes defects in the growth and patterning of the digits and interdigital tissues. Analysis of HoxA13 expression reveals a pattern of localization overlapping with sites of reduced Bmp2 and Bmp7 expression in HoxA13 mutant limbs. HoxA13 regulates Bmp2 and Bmp7 expression, providing a link between HoxA13, its target genes and the specific developmental processes affected by loss of HoxA13 function.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

HOXA13 serves as a biomarker to predict neoadjuvant therapy efficacy in advanced colorectal cancer patients.

Acta biochimica et biophysica Sinica

Liu S,Zhang R,Yang Z,Wang Y,Guo X,Zhao Y,Lin H,Xiang Y,Ding C,Dong Z,Xu C

PA5-76440 was used in Immunohistochemistry to investigate the relationship between HOXA13 expression and Neoadjuvant therapy efficacy.

Sun Dec 25 00:00:00 UTC 2022

Anatomic position determines oncogenic specificity in melanoma.

Nature

Weiss JM,Hunter MV,Cruz NM,Baggiolini A,Tagore M,Ma Y,Misale S,Marasco M,Simon-Vermot T,Campbell NR,Newell F,Wilmott JS,Johansson PA,Thompson JF,Long GV,Pearson JV,Mann GJ,Scolyer RA,Waddell N,Montal ED,Huang TH,Jonsson P,Donoghue MTA,Harris CC,Taylor BS,Xu T,Chaligné R,Shliaha PV,Hendrickson R,Jungbluth AA,Lezcano C,Koche R,Studer L,Ariyan CE,Solit DB,Wolchok JD,Merghoub T,Rosen N,Hayward NK,White RM

PA5-76440 was used in Western Blot, Sample Prep to suggest that the anatomic position of the cell of origin endows it with a unique transcriptional state that makes it susceptible to only certain oncogenic insults.

Fri Apr 01 00:00:00 UTC 2022

生物信息学

蛋白别名: homeo box 1J; homeo box A13; homeobox A13; Homeobox protein Hox-1.10; Homeobox protein Hox-1J; Homeobox protein Hox-A13; homeobox protein HOXA13; hypodactyly; transcription factor HOXA13

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基因别名: Hd; Hox-1.10; HOX1; HOX1J; HOXA13; RGD1562483

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UniProt ID: (Human) P31271, (Mouse) Q62424

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Entrez Gene ID: (Human) 3209, (Rat) 500129, (Mouse) 15398

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功能

DNA binding sequence-specific DNA binding molecular_function transcription factor activity, sequence-specific DNA binding protein binding transcription regulatory region DNA binding

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