Invitrogen

HOXB4 Polyclonal Antibody

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HOXB4 Antibody (PA5-116699) in WB

Western blot analysis of HOXB4 in extracts of various cell lines. Samples were incubated with HOXB4 Polyclonal antibody (Product # PA5-116699) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.

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产品信息

PA5-116699

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

酶联免疫吸附实验 (ELISA)

1 µg/mL

产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthetic peptide corresponding to a sequence within amino acids 50-150 of human HOXB4 (NP_0769201)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.16 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.01% thimerosal

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

AB_2901330

产品详细信息

Positive Samples: HL-60, Mouse liver

Immunogen sequence: PEAGFGRRAA CTVQRYAACR DPGPPPPPPP PPPPPPPPGL SPRAPAPPPA GALLPEPGQR CEAVSSSPPP PPCAQNPLHP SPSHSACKEP VVYPWMRKVH V

靶标信息

HOX homeobox genes play a role both in the early stem cell function as well as in later stages of hematopoietic differentiation. HOXB4, specifically, is a homeotic selector gene implicated in self-renewal of definitive HSCs. Expression of HOXB4 in primitive progenitors combined with culture on hematopoietic stroma induced a switch to the definitive HSC phenotype. Activation of WNT signaling in HSCs induced increased expression of HOXB4. Perturbations of HOX gene expression can cause leukemia.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

仅用于科研。不用于诊断过程。未经明确授权不得转售。