Invitrogen

HOXB7 Polyclonal Antibody

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HOXB7 Antibody (40-2000) in WB

Western Blot analysis of (A) A375, (B) NTERA (NT2/D1), (C) SK-MEL-19, (D) SK-MEL-37, (E) KARPAS 299, (F) SW480, and (G) HT-29 cell lysates using Zymed Rb anti-HOXB7 (Product # 40-2000).

Product Image Gallery

HOXB7 Antibody — Protein expression of HOXB7 following transfection for 72 h: Con-B group, blank control group; Sn group, negative control siRNA; S1 group, S1 transfection group; S2 group, S2 transfection group and S3 group, S3 transfection group. (A) The protein expression level of HOXB7 was measured by western blotting. (B) The optical density for target protein is shown as a proportion of GAPDH optical density. Cells in the S3 group had the lowest HOXB7 protein expression level (***P<0.001, compared with the Con B and Sn groups). HOXB7, homeobox B7. {KD}

产品信息

40-2000

应用

建议稀释比

已发表文章

免疫印迹 (WB)

Assay-dependent

查看7篇已发表文章 7篇已发表文章

免疫组化 (IHC)

- -

免疫细胞化学 (ICC/IF)

Assay-dependent

查看1篇已发表文章 1篇已发表文章

产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide derived from the C-terminal region of the human HOXB7 (homeobox B7, homeobox C1) protein

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.25 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4

内含物

0.1% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

AB_2533454

靶标信息

The homeobox genes encode transcription factors that regulate developmental processes such as body patterning and organogenesis. The mammalian HOX gene complex consists of 39 genes that are located on 4 linkage groups (clusters), dispersed over 4 chromosomes (HOXA, HOXB, HOXC and HOXD). HOXB7 is expressed in most malignant T-cell lines and CD4-positive peripheral blood cells, and is constitutively expressed in both melanoma primary lesions and cell lines. HOXB7 binds to and transactivates bFGF in melanoma cell lines but SkBr3 breast adenocarcinoma is negative for the expression of both HOXB7 and bFGF genes. HOXB7 may be a key activator of tumor-associated neoangiogenesis.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Mitogen-activated protein kinase inhibition augments the T cell response against HOXB7-expressing tumor through human leukocyte antigen upregulation.

Cancer science

Komatsuda H,Wakisaka R,Kono M,Kumai T,Hayashi R,Yamaki H,Sato R,Nagato T,Ohkuri T,Kosaka A,Ohara K,Takahara M,Katada A,Kobayashi H

Published figure using HOXB7 polyclonal antibody (Product # 40-2000) in Western Blot

Wed Feb 01 00:00:00 UTC 2023

Silencing of hsa_circ_0009035 Suppresses Cervical Cancer Progression and Enhances Radiosensitivity through MicroRNA 889-3p-Dependent Regulation of HOXB7.

Molecular and cellular biology

Zhao X,Dong W,Luo G,Xie J,Liu J,Yu F

40-2000 was used in Western Blotting to investigate circular RNAs and microRNAs influencing HoXB7 in cervical cancer.

Fri May 21 00:00:00 UTC 2021

Silencing of hsa_circ_0009035 Suppresses Cervical Cancer Progression and Enhances Radiosensitivity through MicroRNA 889-3p-Dependent Regulation of HOXB7.

Molecular and cellular biology

Zhao X,Dong W,Luo G,Xie J,Liu J,Yu F

40-2000 was used in Western Blotting to investigate circular RNAs and microRNAs influencing HoXB7 in cervical cancer.

Fri May 21 00:00:00 UTC 2021

Long non-coding RNA SNHG8 promotes prostate cancer progression through repressing miR-384 and up-regulating HOXB7.

The journal of gene medicine

Shi Z,Zhang H,Jie S,Yang X,Huang Q,Mao Y,Zhang Y

40-2000 was used in Western Blotting to probe the function of lncRNA small nucleolar RNA host gene 8 (SNHG8) in prostate cancer progression.

Mon Mar 01 00:00:00 UTC 2021

Long non-coding RNA SNHG8 promotes prostate cancer progression through repressing miR-384 and up-regulating HOXB7.

The journal of gene medicine

Shi Z,Zhang H,Jie S,Yang X,Huang Q,Mao Y,Zhang Y

40-2000 was used in Western Blotting to probe the function of lncRNA small nucleolar RNA host gene 8 (SNHG8) in prostate cancer progression.

Mon Mar 01 00:00:00 UTC 2021

Psoralen Suppresses Cisplatin-Mediated Resistance and Induces Apoptosis of Gastric Adenocarcinoma by Disruption of the miR196a-HOXB7-HER2 Axis.

Cancer management and research

Jin L,Ma XM,Wang TT,Yang Y,Zhang N,Zeng N,Bai ZG,Yin J,Zhang J,Ding GQ,Zhang ZT

40-2000 was used in Western Blotting to investigate the impact of psoralen on miR-196a-5p expression and function, and to reveal the mechanism underlying miR-196a-5p-mediated inhibition and the reversal of cisplatin resistance.

Thu Apr 14 00:00:00 UTC 2022

Psoralen Suppresses Cisplatin-Mediated Resistance and Induces Apoptosis of Gastric Adenocarcinoma by Disruption of the miR196a-HOXB7-HER2 Axis.

Cancer management and research

Jin L,Ma XM,Wang TT,Yang Y,Zhang N,Zeng N,Bai ZG,Yin J,Zhang J,Ding GQ,Zhang ZT

Thu Apr 14 00:00:00 UTC 2022

Targeting HOX/PBX dimer formation as a potential therapeutic option in esophageal squamous cell carcinoma.

Cancer science

Shen LY,Zhou T,Du YB,Shi Q,Chen KN

40-2000 was used in Immunocytochemistry-immunoflourescence to explore whether oesophageal squamous cell carcinoma cells are sensitive to HXR9 disrupting the interaction between multiple HOX proteins and their cofactor PBX.

Wed May 01 00:00:00 UTC 2019

The roles of HOXB7 in promoting migration, invasion, and anti-apoptosis in gastric cancer.

Journal of gastroenterology and hepatology

Joo MK,Park JJ,Yoo HS,Lee BJ,Chun HJ,Lee SW,Bak YT

40-2000 was used in western blot to study promotion of invasion, migration and anti-apoptosis in gastric cancer and the role of HOXB7

Sat Oct 01 00:00:00 UTC 2016

HOXB7-S3 inhibits the proliferation and invasion of MCF-7 human breast cancer cells.

Molecular medicine reports

Ma R,Zhang D,Hu PC,Li Q,Lin CY

40-2000 was used in western blot to determine the effects of HOXB7 on the proliferation and invasion of breast cancer cells.

Thu Oct 01 00:00:00 UTC 2015

HOXB7 expression by myeloma cells regulates their pro-angiogenic properties in multiple myeloma patients.

Leukemia

Storti P,Donofrio G,Colla S,Airoldi I,Bolzoni M,Agnelli L,Abeltino M,Todoerti K,Lazzaretti M,Mancini C,Ribatti D,Bonomini S,Franceschi V,Pistoia V,Lisignoli G,Pedrazzini A,Cavicchi O,Neri A,Rizzoli V,Giuliani N