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产品信息
PA5-103891
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human HOXB8(Accession P17481), corresponding to amino acid residues P61-K111.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2853223
产品详细信息
Antibody detects endogenous levels of total HOXB8.
靶标信息
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with colorectal cancer. Mice that have had the murine ortholog of this gene knocked out exhibit an excessive pathologic grooming behavior. This behavior is similar to the behavior of humans suffering from the obsessive-compulsive spectrum disorder trichotillomania.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: homeo box 2D; homeo box B8; homeobox gene B8; Homeobox protein Hox-2.4; Homeobox protein Hox-2D; Homeobox protein Hox-B8; homeobox protein R1a; Hox2.4 homeobox homolog
基因别名: Hox-2.4; HOX2; HOX2D; Hox2r1a; Hoxb-8; HOXB8
UniProt ID: (Human) P17481, (Mouse) P09632
Entrez Gene ID: (Human) 3218, (Rat) 24457, (Mouse) 15416
transcription, DNA-templated
regulation of transcription, DNA-templated
grooming behavior
adult locomotory behavior
anterior/posterior pattern specification
sensory perception of pain
dorsal spinal cord development
negative regulation of myeloid cell differentiation
embryonic skeletal system morphogenesis
multicellular organism development
skeletal system morphogenesis
