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This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development. Mutations in this gene have been associated with Wilm's tumor and congenital vertical talus and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: d10; homeo box 4D; homeo box D10; Homeobox protein Hox-4D; Homeobox protein Hox-4E; Homeobox protein Hox-D10; Hox-45
基因别名: Hox-4.4; HOX4; HOX4D; HOX4E; HOXD10
UniProt ID: (Human) P28358
Entrez Gene ID: (Human) 3236