Invitrogen

HOXD13 Polyclonal Antibody

HOXD13 Antibody in Immunocytochemistry (ICC/IF)

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HOXD13 Antibody (PA5-66661) in ICC/IF

Immunofluorescent staining of HOXD13 in human cell line SK-MEL-30 shows localization to nucleoplasm. Samples were probed using a HOXD13 Polyclonal Antibody (Product # PA5-66661).

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产品信息

PA5-66661

应用

建议稀释比

已发表文章

免疫细胞化学 (ICC/IF)

0.25-2 µg/mL

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产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant Human HOXD13. Recombinant protein control fragment (Product #RP-107309).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2662801

产品详细信息

Immunogen sequence: SFYQGYTSPYQ HVPGYIDMVS TFGSGEPRHE AYISMEGYQS WTLANGWNSQ VYCTKDQPQG SHFWKSSFPG

Highest antigen sequence identity to the following orthologs - mouse 99%, rat 99%.

靶标信息

HOXD13 (homeobox protein D13) belongs to a class of transcription factors called homeobox proteins. In vertebrates, homeobox are found in clusters called A, B, C, and D on four separate chromosomes. Expression of homeobox proteins is spatially and temporally regulated during embryonic development. The gene encoding HOXD13 is part of the D cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. Mutations in the HOXD13 gene cause synpolydactyly.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Unblending of Transcriptional Condensates in Human Repeat Expansion Disease.

Cell

Basu S,Mackowiak SD,Niskanen H,Knezevic D,Asimi V,Grosswendt S,Geertsema H,Ali S,Jerković I,Ewers H,Mundlos S,Meissner A,Ibrahim DM,Hnisz D

PA5-66661 was used in Immunocytochemistry to report that alanine repeat expansions in the HOXD13 TF, which cause hereditary synpolydactyly in humans, alter its phase separation capacity and its capacity to co-condense with transcriptional co-activators.