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This gene encodes a heparanase enzyme. The encoded protein is a endoglycosidase that degrades heparin sulfate proteoglycans located on the extracellular matrix and cell surface. This protein may be involved in biological processes involving remodeling of the extracellular matrix including angiogenesis and tumor progression. Alternate splicing results in multiple transcript variants.
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Protein Aliases: heparanase 3; heparanase-like protein; Hpa2; Inactive heparanase-2
Gene Aliases: HPA2; HPR2; HPSE2; UFS; UFS1
UniProt ID: (Human) Q8WWQ2
Entrez Gene ID: (Human) 60495
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