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产品信息
PA5-82191
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2789352
产品详细信息
Immunogen sequence: PAPGFPFPPP WMGMPLPPPF AFPPMPVPPA GFAGLTPEEL RALEGHERQH LEARLQSLRN IHTLLDAAML QINQYLTVLA SLGPPRPATS VNSTEETATT VVAAASSTSI PSSEATTPTP GASPPAPEME RPPAPESVGT
靶标信息
HRD1 is a ubiquitin ligase whose expression is induced by the unfolded protein response (UPR) following endoplasmic reticulum stress. Expression of HRD1 protects cells from apoptosis by inducing degradation of abnormally processed proteins that accumulate in the endoplasmic reticulum. HRD1 is expressed in many tissues, strongly expressed in brain, pancreas, liver, kidney and skeletal muscle. It has been reported that Synoviolin/Hrd1 (expressed in rheumatoid synovium) is a novel causative factor for arthropathy by triggering synovial cell outgrowth through its anti-apoptotic effects. HRD1 contains one ring-type zinc finger.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: E3 ubiquitin-protein ligase synoviolin; HMG-coA reductase degradation 1 homolog; MGC40372; RING-type E3 ubiquitin transferase synoviolin; Synovial apoptosis inhibitor 1; synovial apoptosis inhibitor 1, synoviolin
基因别名: DER3; HRD1; KIAA1810; SYVN1
UniProt ID: (Human) Q86TM6
Entrez Gene ID: (Human) 84447
protein ubiquitination
protein N-linked glycosylation via asparagine
ER-associated ubiquitin-dependent protein catabolic process
endoplasmic reticulum unfolded protein response
retrograde protein transport, ER to cytosol
IRE1-mediated unfolded protein response
ERAD pathway
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
protein stabilization
protein K48-linked ubiquitination
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
endoplasmic reticulum mannose trimming
