Invitrogen

HRG Polyclonal Antibody

View all (14) HRG antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-97051

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 20-260 of human HRG (NP_0004031)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.78 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2808853

Product Specific Information

Immunogen sequence: SPTDCSAVEP EAEKALDLIN KRRRDGYLFQ LLRIADAHLD RVENTTVYYL VLDVQESDCS VLSRKYWNDC EPPDSRRPSE IVIGQCKVIA TRHSHESQDL RVIDFNCTTS SVSSALANTK DSPVLIDFFE DTERYRKQAN KALEKYKEEN DDFASFRVDR IERVARVRGG EGTGYFVDFS VRNCPRHHFP RHPNVFGFCR ADLFYDVEAL DLESPKNLVI NCEVFDPQEH ENINGVPPHL G; Positive Samples: Mouse pancreas

Target Information

HRG contains two cystatin-like domains and is located in plasma and platelets. The physiological function has not been determined but it is known that the protein binds heme, dyes and divalent metal ions. It can inhibit rosette formation and interacts with heparin, thrombospondin and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potential prothrombotic effect. Mutations in this gene lead to thrombophilia due to abnormal histidine-rich glycoprotein levels.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: DKFZp779H1622; Histidine-proline-rich glycoprotein; Histidine-rich glycoprotein; Histidine-rich glycoprotein 1; HPRG; HRG1

View more View less

Gene Aliases: AI265597; AW413091; D16jh2; D18020; HPRG; Hrg; HRG1; Hrgp

View more View less

UniProt ID: (Rat) Q99PS8, (Mouse) Q9ESB3

View more View less

Entrez Gene ID: (Rat) 171016, (Mouse) 94175

View more View less

Function(s)
molecular_function serine-type endopeptidase inhibitor activity cysteine-type endopeptidase inhibitor activity receptor binding heparin binding zinc ion binding immunoglobulin binding heme binding heparan sulfate proteoglycan binding metal ion binding protein binding protease inhibitor
Process(es)
positive regulation of immune response to tumor cell negative regulation of cell adhesion biological_process negative regulation of cell proliferation regulation of gene expression regulation of platelet activation negative regulation of lamellipodium assembly negative regulation of endopeptidase activity response to organic cyclic compound heme transport negative regulation of angiogenesis platelet activation regulation of blood coagulation negative regulation of cell growth regulation of actin cytoskeleton organization negative regulation of cell adhesion mediated by integrin regulation of transcription from RNA polymerase II promoter in response to iron fibrinolysis positive regulation of apoptotic process regulation of protein complex assembly negative regulation of blood vessel endothelial cell migration regulation of peptidyl-tyrosine phosphorylation defense response to fungus positive regulation of focal adhesion assembly negative regulation of fibrinolysis heme export negative regulation of vascular endothelial growth factor signaling pathway positive regulation of blood vessel remodeling negative regulation of endothelial cell chemotaxis angiogenesis chemotaxis blood coagulation hemostasis
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support