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HRH1 Antibody (PA5-120691) in WB
Western blot analysis of HRH1 in extracts of various cell lines. Samples were incubated with HRH1 Polyclonal antibody (Product # PA5-120691) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.
产品信息
PA5-120691
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 250-340 of human HRH1 (NP_000852.1).
偶联物
形式
Liquid
浓度
0.73 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2914263
产品详细信息
Positive test controls include: U-251MG, Mouse liver, Rat liver.
Immunogen sequence: KPGKESPWEV LKRKPKDAGG GSVLKSPSQT PKEMKSPVVF SQEDDREVDK LYCFPLDIVH MQAAAEGSSR DYVAVNRSHG QLKTDEQGLN T
靶标信息
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene was thought to be intronless until recently. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. Multiple alternatively spliced variants, encoding the same protein, have been identified.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Bordetella pertussis induced histamine sensitization; H1 receptor; H1-R; H1R; HH1R; Histamine H1 receptor; Histamine H1-R; histamine receptor; histamine receptor, subclass H1
基因别名: Bphs; H1-R; H1R; HH1R; Hir; hisH1; Hisr; HRH1
UniProt ID: (Human) P35367, (Mouse) P70174, (Rat) P31390
Entrez Gene ID: (Human) 3269, (Mouse) 15465, (Rat) 24448
inflammatory response
G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
memory
visual learning
regulation of vasoconstriction
positive regulation of inositol trisphosphate biosynthetic process
regulation of vascular permeability
positive regulation of vasoconstriction
inositol phosphate-mediated signaling
regulation of synaptic plasticity
eosinophil chemotaxis
modulation of synaptic transmission
cellular response to histamine
signal transduction
chemical synaptic transmission
sensory perception of chemical stimulus
negative regulation of steroid biosynthetic process
positive regulation of nitric oxide biosynthetic process
rhythmic process
calcium ion import
calcium ion transmembrane transport
manganese ion transmembrane transport
G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
response to gravity
