Invitrogen

HSD17B1 Polyclonal Antibody

HSD17B1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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HSD17B1 Antibody (PA5-42058) in IHC (P)

Immunohistochemistry (paraffin-embedded) analysis of human kidney tissue using an anti-HSD17B1 polyclonal antibody (Product # PA5-42058).

HSD17B1 Antibody in Immunohistochemistry (IHC)

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产品信息

PA5-42058

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.2-1 µg/mL

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免疫组化 (IHC)

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免疫组化（石蜡） (IHC (P))

4-8 µg/mL

产品规格

种属反应

Human, Mouse

已发表种属

Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide directed towards the N-terminal of human HSD17B1 (aa 1-50).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS with 2% sucrose

内含物

0.09% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

AB_2609429

产品详细信息

Peptide sequence: MARTVVLITG CSSGIGLHLA VRLASDPSQS FKVYATLRDL KTQGRLWEAA

Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 91%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%

靶标信息

HSD17B1 is favors the reduction of estrogens and androgens. It also has 20-alpha-HSD activity. It uses preferentially NADH.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Platelets induce increased estrogen production through NF-κB and TGF-β1 signaling pathways in endometriotic stromal cells.

Scientific reports

Qi Q,Liu X,Zhang Q,Guo SW

Published figure using HSD17B1 polyclonal antibody (Product # PA5-42058) in Immunohistochemistry

Tue Jan 28 00:00:00 UTC 2020

Platelets induce increased estrogen production through NF-κB and TGF-β1 signaling pathways in endometriotic stromal cells.

Scientific reports

Qi Q,Liu X,Zhang Q,Guo SW

Published figure using HSD17B1 polyclonal antibody (Product # PA5-42058) in Immunohistochemistry

Tue Jan 28 00:00:00 UTC 2020

Estrogen biosynthesis in cultured skeletal muscle cells (L6) induced by amino acids.

Genes & nutrition

Iresjö BM,Landin A,Ohlsson C,Lundholm K

PA5-42058 was used in Western Blotting to investigate if increased availability of amino acids induced biosynthesis of sex steroids in skeletal muscles.

Mon Apr 11 00:00:00 UTC 2022

生物信息学

蛋白别名: 17-beta-HSD 1; 17-beta-hydroxysteroid dehydrogenase type 1; 20 alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; E2DH; Estradiol 17-beta-dehydrogenase 1; estradiol 17-beta-dehydrogenase-1; hydroxysteroid (17-beta) dehydrogenase 1 isoform; Placental 17-beta-hydroxysteroid dehydrogenase; Short chain dehydrogenase/reductase family 28C member 1; short chain dehydrogenase/reductase family 28CE, member 1

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基因别名: 17beta-HSD; 17HSDB1; E17KSR; E2DH; EDH17B1; EDH17B2; EDHB17; HSD17; HSD17B1; Hsd17ba; SDR28C1

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UniProt ID: (Human) P14061, (Mouse) P51656

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Entrez Gene ID: (Human) 3292, (Mouse) 15485

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功能

catalytic activity estradiol 17-beta-dehydrogenase activity testosterone dehydrogenase (NAD+) activity oxidoreductase activity dehydrogenase

参与通路

steroid biosynthetic process estrogen biosynthetic process estrogen metabolic process oxidation-reduction process bone development testosterone biosynthetic process cellular response to metal ion lipid metabolic process metabolic process