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Product Details
PA5-21522
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fragment corresponding to a region within amino acids 355 and 645 of HSD17B4 (Uniprot ID#P51659)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_11153201
Product Specific Information
Recommended positive controls: Rat heart.
Predicted reactivity: Mouse (87%), Rat (88%), Pig (88%), Bovine (88%), Guinea pig (84%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Peroxisomal multifunctional enzyme type 2 is a protein that in humans is encoded by the HSD17B4 gene. The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). An apparent pseudogene of this gene is present on chromosome 8. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: (3R)-hydroxyacyl-CoA dehydrogenase; 17-beta-HSD 4; 17-beta-HSD IV; 17-beta-hydroxysteroid dehydrogenase 4; 17beta-estradiol dehydrogenase type IV; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase; beta-hydroxyacyl dehydrogenase; beta-keto-reductase; D-3-hydroxyacyl-CoA dehydratase; D-bifunctional protein; D-bifunctional protein, peroxisomal; DBP; Enoyl-CoA hydratase 2; hydroxysteroid (17-beta) dehydrogenase 4; hydroxysteroid dehydrogenase 4; MFE-2; MFP-2; Multifunctional protein 2; Peroxisomal multifunctional enzyme type 2; peroxisomal multifunctional enzyme type II; peroxisomal multifunctional protein 2; Short chain dehydrogenase/reductase family 8C member 1; short chain dehydrogenase/reductase family 8C, member 1
Gene Aliases: DBP; EDH17B4; HSD17B4; MFE-2; MPF-2; PRLTS1; SDR8C1
UniProt ID: (Human) P51659, (Rat) P97852
Entrez Gene ID: (Human) 3295, (Rat) 79244
3-hydroxyacyl-CoA dehydrogenase activity
receptor binding
long-chain-enoyl-CoA hydratase activity
isomerase activity
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity
protein homodimerization activity
17-beta-hydroxysteroid dehydrogenase (NAD+) activity
testosterone dehydrogenase [NAD(P)] activity
very long-chain fatty acid metabolic process
osteoblast differentiation
fatty acid beta-oxidation
bile acid biosynthetic process
androgen metabolic process
estrogen metabolic process
fatty acid beta-oxidation using acyl-CoA oxidase
alpha-linolenic acid metabolic process
very long-chain fatty-acyl-CoA metabolic process
medium-chain fatty-acyl-CoA metabolic process
Sertoli cell development
metabolic process
cholesterol metabolic process
oxidation-reduction process
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