Invitrogen

HSPA1A Monoclonal Antibody (C2)

View all (34) HSPA1A antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-50937

Applications
Tested Dilution
Publications

Western Blot (WB)

0.01-5 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent
-
Product Specifications

Species Reactivity

Bovine, Dog, Guinea pig, Human, Rabbit

Host/Isotype

Mouse / IgG2b, kappa

Class

Monoclonal

Type

Antibody

Clone

C2

Immunogen

Recombinant Human HSPA1A protein, Asp275-Asp641 (Accession #P08107(P0DMV8))
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A/G

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.05% Proclin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_3093424

Target Information

This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: 70 kda heat shock protein-2; chaperone; dnaK-type molecular chaperone HSP70-1; epididymis secretory protein Li 103; heat shock 70 kD protein 1; heat shock 70 kD protein 2; Heat shock 70 kDa protein 1; heat shock 70 kDa protein 1/2; Heat shock 70 kDa protein 1A; heat shock 70 kDa protein 1A/1B; Heat shock 70 kDa protein 1B; Heat shock 70 kDa protein 2; heat shock 70kD protein 1A; heat shock 70kDa protein 1A; heat shock 70kDa protein 1B; Heat Shock Protein 70; Heat shock protein family A member 1A; Heat shock protein family A member 1B; heat shock-induced protein; heat-shock 70-kilodalton protein 1A; heat-shock 70-kilodalton protein 1B; HSP70-1; HSP70-1/HSP70-2; HSP70-2; HSP70.1; HSP70.1/HSP70.2; HSP70.2

View more View less

Gene Aliases: HEL-S-103; HSP70; HSP70-1; HSP70-1A; HSP70-2; HSP70.1; HSP70I; HSP72; HSPA1; HSPA1A; HSPA1B; HSPA2; HSX70

View more View less

UniProt ID: (Human) P0DMV9, (Bovine) Q27965

View more View less

Entrez Gene ID: (Human) 3303, (Bovine) 282254

View more View less

Function(s)
virus receptor activity G-protein coupled receptor binding receptor binding protein binding ATP binding ATPase activity enzyme binding heat shock protein binding ubiquitin protein ligase binding ATPase activity, coupled histone deacetylase binding protein binding involved in protein folding unfolded protein binding C3HC4-type RING finger domain binding cadherin binding involved in cell-cell adhesion
Process(es)
telomere maintenance DNA repair positive regulation of gene expression regulation of cell death regulation of protein ubiquitination negative regulation of protein ubiquitination positive regulation of interleukin-8 production cellular response to oxidative stress cellular response to heat protein refolding regulation of mRNA stability ATP metabolic process viral entry into host cell protein stabilization positive regulation of NF-kappaB transcription factor activity negative regulation of cell death cellular heat acclimation positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway negative regulation of inclusion body assembly cell-cell adhesion regulation of cellular response to heat negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway positive regulation of endoribonuclease activity positive regulation of tumor necrosis factor-mediated signaling pathway positive regulation of mRNA endonucleolytic cleavage involved in unfolded protein response negative regulation of extrinsic apoptotic signaling pathway in absence of ligand positive regulation of microtubule nucleation regulation of mitotic spindle assembly
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support