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Positive Samples: A-549, 293T, Mouse kidney, Mouse brain, Rat thymus
Immunogen sequence: MRKIDLCLSS EGSEVILATS SDEKHPPENI IDGNPETFWT TTGMFPQEFI ICFHKHVRIE RLVIQSYFVQ TLKIEKSTSK EPVDFEQWIE KDLVHTEGQL QNEEIVAHDG SATYLRFIIV SAFDHFASVH SVSAEGTVVS NLSS
HSPB11 (Heat shock protein beta-11), also known as IFT25, was originally identified as a small heat shock protein. Recently it has been identified as a component of IFT complex B. It has been demonstrated that IFT25 is not required for ciliary assembly but is required for proper Hedgehog signaling, which in mammals occurs within cilia. Cilia lacking IFT25 have defects in the signal-dependent transport of multiple Hedgehog components and fail to activate the pathway upon stimulation.
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仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Heat shock protein; Heat shock protein beta-11; heat shock protein family B (small), member 11; Heat shock protein family B member 11; HSP; Hspb11; Hspb11 heat shock protein family B (small), member 11; intraflagellar transport 25 homolog; Intraflagellar transport protein 25 homolog; Placental protein 25; placental protein 25 homolog; PP25
基因别名: 2900042B11Rik; C1orf41; HSPB11; HSPC034; HSPCO34; IFT25; PP25
UniProt ID: (Human) Q9Y547, (Mouse) Q9D6H2
Entrez Gene ID: (Human) 51668, (Mouse) 72938, (Rat) 685284