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产品信息
PA5-147424
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Human HTR1B
偶联物
形式
Liquid
浓度
0.05 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
0
产品详细信息
Immunogen sequence: MEEPGAQCAPP PPAGSETWVP QANLSSAPSQ NCSAKDYIYQ DS
Highest antigen sequence identity to the following orthologs - mouse 67%, rat 72%.
靶标信息
Serotonin (5-hydroxytryptamine, 5-HT), originally discovered as a serum factor plays important roles in regulating diverse biological processes in central and peripheral nervous systems, cardiovascular systems, and gastrointestinal systems. Molecular cloning studies have identified 5 receptors belonging to the 5-HT1 subtypes. These receptors are negatively coupled to adenylyl cyclase. Radioligand binding studies suggest the presence of 5-HT1B (formerly known as 5-HT1DbR) sites in substantia nigra, dorsal subiculum, globus pallidus, and superior collicum. In situ hybridization studies show abundance of 5-HT1BR mRNA in CA1 pyramidal cells of hippocampus, Purkinje cells of cerebellum, olfactory tubercle, subthalamic nucleus and somewhat lower levels in the caudate-putamen, cortical areas, thalamic and hypothalamic nuclei.
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生物信息学
蛋白别名: 5-HT-1B; 5-HT-1D-beta; 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled; 5-hydroxytryptamine receptor 1B; 5HT1B Receptor; S12; Serotonin 1D beta receptor; Serotonin receptor 1B
基因别名: 5-HT-1B; 5-HT-1D-beta; 5-HT1B; 5-HT1DB; HTR1B; HTR1D2; HTR1DB; S12
UniProt ID: (Human) P28222
Entrez Gene ID: (Human) 3351
G-protein coupled receptor internalization
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
adenylate cyclase-inhibiting serotonin receptor signaling pathway
protein kinase C-activating G-protein coupled receptor signaling pathway
chemical synaptic transmission
regulation of dopamine secretion
negative regulation of serotonin secretion
negative regulation of cAMP biosynthetic process
negative regulation of synaptic transmission, GABAergic
cellular response to drug
response to cocaine
vasoconstriction
drinking behavior
response to ethanol
bone remodeling
regulation of behavior
response to mineralocorticoid
negative regulation of synaptic transmission, glutamatergic
cellular response to alkaloid
cellular response to temperature stimulus
