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Product Details
PA5-33308
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic 16 amino acid peptide from C-terminus of human 5HT2C Receptor.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2550692
Product Specific Information
Percent identity with other species by BLAST analysis: Human, Chimpanzee (100%) Gorilla, Orangutan, Monkey, Panda (94%) Gibbon, Pig (88%) Elephant, Rabbit, Horse (81%).
Target Information
Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in humans have reported abnormalities in patterns of 5-HT2C editing in depressed suicide victims.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 5-HT-1C; 5-HT-2C; 5-HT1c receptor; 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled; 5-hydroxytryptamine receptor 1C; 5-hydroxytryptamine receptor 2C; 5HT2C Receptor; HGNC:5295; RP11-810O3.1; RP23-15B7.1; serotonin 5-HT-1C receptor; serotonin 5-HT-2C receptor; Serotonin receptor 2C
Gene Aliases: 5-HT1C; 5-HT2C; 5-HTR2C; 5HTR2C; HTR1C; HTR2C
UniProt ID: (Human) P28335
Entrez Gene ID: (Human) 3358
behavioral fear response
cGMP biosynthetic process
cellular calcium ion homeostasis
phospholipase C-activating G-protein coupled receptor signaling pathway
phospholipase C-activating serotonin receptor signaling pathway
serotonin receptor signaling pathway
chemical synaptic transmission
locomotory behavior
feeding behavior
positive regulation of phosphatidylinositol biosynthetic process
regulation of neurological system process
regulation of appetite
response to drug
regulation of corticotropin-releasing hormone secretion
positive regulation of fat cell differentiation
release of sequestered calcium ion into cytosol
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
positive regulation of ERK1 and ERK2 cascade
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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