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Product Details
PA1-30207
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
This antibody was developed by immunizing rabbits with a mixture of synthetic peptides corresponding to amino acids 27-42 (RATQAHSTTQPALLRL) and 427-442 (LSSIRHSLEKRDEMRE) of rat 5-HT3 Receptor, accession number P35563
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein G
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2124574
Product Specific Information
A suggested positive control for this product is human brain tissue.
Target Information
The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine, a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 5-HT-3; 5-HT3 receptor; 5-HT3-A; 5-HT3A; 5-HT3R; 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic; 5-hydroxytryptamine receptor 3; 5-hydroxytryptamine receptor 3A; 5HT3 serotonin receptor; serotonin receptor; Serotonin receptor 3A; Serotonin-gated ion channel receptor; truncated receptor
Gene Aliases: 5-HT-3; 5-HT3; 5-HT3A; 5-HT3R; 5HT3; 5HT3R; HTR3; HTR3A
UniProt ID: (Human) P46098, (Rat) P35563, (Mouse) P23979
Entrez Gene ID: (Human) 3359, (Rat) 79246, (Mouse) 15561
acetylcholine-activated cation-selective channel activity
serotonin-activated cation-selective channel activity
voltage-gated potassium channel activity
protein binding
acetylcholine receptor activity
serotonin-gated cation channel activity
acetylcholine binding
serotonin binding
G-protein coupled serotonin receptor activity
extracellular ligand-gated ion channel activity
ligand-gated ion channel activity
ligand-gated ion channel
signal transduction
synaptic transmission, cholinergic
ion transmembrane transport
response to cocaine
response to ethanol
cellular response to growth factor stimulus
potassium ion transmembrane transport
cation transport
serotonin receptor signaling pathway
chemical synaptic transmission
cation transmembrane transport
transport
ion transport
regulation of ion transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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