Invitrogen

HTR3B Polyclonal Antibody

HTR3B Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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HTR3B Antibody (PA5-41033) in IHC (P)

Immunohistochemistry (paraffin-embedded) analysis of human spleen tissue using an anti-HTR3B polyclonal antibody (Product # PA5-41033).

HTR3B Antibody in Immunohistochemistry (IHC)

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产品信息

PA5-41033

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.2-1 µg/mL

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免疫组化 (IHC)

Assay-Dependent

免疫组化（石蜡） (IHC (P))

4-8 µg/mL

产品规格

种属反应

Human, Mouse

已发表种属

Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide directed towards the N-terminal of human HTR3B (aa 8-57).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS with 2% sucrose

内含物

0.09% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

AB_2609926

产品详细信息

Peptide sequence: PLWACILVAA GILATDTHHP QDSALYHLSK QLLQKYHKEV RPVYNWTKAT

Sequence homology: Cow: 79%; Dog: 77%; Guinea Pig: 79%; Human: 100%; Mouse: 77%; Pig: 86%; Rabbit: 86%; Rat: 79%

靶标信息

The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit B of the type 3 receptor for 5-hydroxytryptamine, a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Human-derived gut microbiota modulates colonic secretion in mice by regulating 5-HT₃ receptor expression via acetate production.

American journal of physiology. Gastrointestinal and liver physiology

Bhattarai Y,Schmidt BA,Linden DR,Larson ED,Grover M,Beyder A,Farrugia G,Kashyap PC

PA5-41033 was used in Western Blotting to find that gut microbiota alters serotonin (5-HT)-evoked intestinal secretion in a 5-HT3 receptor-dependent mechanism and gut microbiota metabolite acetate alters 5-HT3 receptor expression in colonoids.

Sat Jul 01 00:00:00 UTC 2017

生物信息学

蛋白别名: 5-HT3 receptor subunit B; 5-HT3-B; 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic; 5-hydroxytryptamine 3 receptor B subunit; 5-hydroxytryptamine receptor 3B; Serotonin receptor 3B; serotonin-gated ion channel subunit

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基因别名: 5-HT3B; HTR3B

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UniProt ID: (Human) O95264, (Mouse) Q9JHJ5

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Entrez Gene ID: (Human) 9177, (Mouse) 57014

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功能

acetylcholine-activated cation-selective channel activity G-protein coupled serotonin receptor activity serotonin-activated cation-selective channel activity acetylcholine receptor activity acetylcholine binding extracellular ligand-gated ion channel activity ligand-gated ion channel activity ligand-gated ion channel

参与通路

serotonin receptor signaling pathway synaptic transmission, cholinergic ion transmembrane transport cation transmembrane transport transport ion transport