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产品信息
PA5-58737
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2642591
产品详细信息
Immunogen sequence: GIIISVKTRS ERQLLRLKQM NVQLAAKIQH LEFSCSEKEQ EIERLNKLLR QHGLLGEVN
Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 86%.
靶标信息
HVCN1 (hydrogen voltage-gated channel 1), a voltage gated proton channel protein that is highly expressed in immune tissues, mediates the proton conductances required by phagocytic leukocytes for the oxidative burst that underlies microbial killing. HVCN1 moderates the voltage-dependent proton permeability of excitable membranes by allowing the flow of protons in accordance to their electrochemical gradient. HVCN1 is sensitive to zinc ions, and can be inhibited by them. HVCN1 may represent a new therapeutic target for B cell malignancies on continued signaling via the B cell antigen receptor.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: HV1; Hydrogen voltage-gated channel 1; Voltage sensor domain-only protein; Voltage-gated hydrogen channel 1
基因别名: HV1; HVCN1; UNQ578/PRO1140; VSOP
UniProt ID: (Human) Q96D96
Entrez Gene ID: (Human) 84329
