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HYAL1 Antibody (PA5-142277) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of HYAL1 in HeLa cells using HYAL1 Polyclonal Antibody (Product # PA5-142277). Cells were fixed with paraformaldehyde, permeabilized with 0.15% Triton, and incubated with the primary antibody for 1hr (10 µg/mL) followed by Alexa Fluor 488 secondary antibody (2 µg/mL), showing cytoplasmic staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10 µg/mL) followed by Alexa Fluor 488 secondary antibody (2 µg/mL).
产品信息
PA5-142277
产品规格
种属反应
Human
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide with sequence ENTRTKESCQAIKEY.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2932929
产品详细信息
Additional Information: This antibody is expected to recognise isoform 1 (NP_009296.1), isoform 3 (NP_695015.1) and isoform 5 (NP_695017.1).
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:128,000.
靶标信息
This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Hyal-1; Hyaluronidase; Hyaluronidase-1; Hyaluronoglucosaminidase-1; LuCa-1; Lung carcinoma protein 1; plasma hyaluronidase; tumor suppressor LUCA-1
基因别名: HYAL-1; HYAL1; LUCA1; MPS9; NAT6
UniProt ID: (Human) Q12794
Entrez Gene ID: (Human) 3373
response to reactive oxygen species
carbohydrate metabolic process
inflammatory response
response to virus
positive regulation of epithelial cell migration
chondroitin sulfate catabolic process
hyaluronan metabolic process
hyaluronan biosynthetic process
hyaluronan catabolic process
positive regulation of cell growth
negative regulation of cell growth
cellular response to platelet-derived growth factor stimulus
cellular response to fibroblast growth factor stimulus
positive regulation of angiogenesis
positive regulation of cell adhesion
positive regulation of growth
response to antibiotic
positive regulation of epithelial cell proliferation
cartilage development
embryonic skeletal joint morphogenesis
cellular response to interleukin-1
cellular response to tumor necrosis factor
cellular response to pH
cellular response to UV-B
positive regulation of hyaluranon cable assembly
