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产品信息
PA5-142825
产品规格
种属反应
Human,
Pig
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide with sequence C-STVPEKKTPKSP.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2933468
产品详细信息
Additional Information: This antibody is expected to recognize both reported isoforms (NP_005134.1; NP_001119574.1).
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:8,000.
靶标信息
As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity, and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. [PMID: 21248165]. The uncleaved form of allele alpha-2 (2-2), known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens. [PMID: 21248165]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: binding peptide; Haptoglobin; haptoglobin alpha 1S; haptoglobin alpha(1S)-beta; haptoglobin alpha(2FS)-beta; haptoglobin, alpha polypeptide; haptoglobin, beta polypeptide; Zonulin
基因别名: BP; HP; HP2ALPHA2; HPA1S
UniProt ID: (Human) P00738, (Pig) Q8SPS7
Entrez Gene ID: (Human) 3240, (Pig) 397061
immune system process
receptor-mediated endocytosis
defense response
acute-phase response
positive regulation of cell death
response to hydrogen peroxide
defense response to bacterium
negative regulation of oxidoreductase activity
cellular oxidant detoxification
negative regulation of hydrogen peroxide catabolic process
