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Hemoglobin gamma-1,2 Antibody (MA5-32603) in ICC/IF
Immunocytochemical analysis of Fetal Hemoglobin in PC-12 cells using a Fetal Hemoglobin Monoclonal antibody (Product # MA5-32603) as seen in red. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
产品信息
MA5-32603
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
JM84-10
抗原
Synthetic peptide within Human HBG1/2 aa 2-45
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2809880
产品详细信息
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
Hemorrhage of cells from an Rh+ fetus into the circulation of an Rh- mother may result in the formation of Rh-reactive antibodies in the mother. Rh hemolytic anemia in a subsequent Rh+ fetus may result from placental transfer of antibodies formed in the mother to the fetus. Although the volume of fetal erythrocytes found in the maternal circulation during pregnancy and immediately post-partum is reported to be small and of uncertain clinical significance in many cases, substantial hemorrhage may result from a number of causes including fetal or maternal trauma and placental defects. Erythrocytes containing fetal hemoglobin may be found in individuals of any age, but with lower amounts of fetal hemoglobin compared to fetal red cells. These cells have been termed F cells. High levels of F cells may also exist in adults with a heterogeneous group of genetic disorders of uncertain etiology, referred to as Hereditary Persistence of Fetal Hemoglobin. Other clinical conditions causing significant levels of anemia may also result in elevated levels of F cells. Several clinical conditions have been described with increased levels of F cells. These conditions include hereditary anemic diseases such as sickle cell anemia and thalassemia major.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: A-gamma globin; abnormal hemoglobin; G-gamma globin Paulinia; gamma A hemoglobin; gamma globin; Gamma-1-globin; Gamma-2-globin; Hb F Agamma; Hb F Ggamma; Hemoglobin gamma-1 chain; Hemoglobin gamma-2 chain; Hemoglobin gamma-A chain; Hemoglobin gamma-G chain; Hemoglobin subunit gamma-1; Hemoglobin subunit gamma-2; hemoglobin, gamma A; hemoglobin, gamma G; hemoglobin, gamma, regulator of; methemoglobin
基因别名: HBG-T1; HBG-T2; HBG1; HBG2; HBGA; HBGR; HSGGL1; PRO2979; TNCY
UniProt ID: (Human) P69891, (Human) P69892
Entrez Gene ID: (Human) 3047, (Human) 3048
