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产品信息
PA5-29154
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 1 and 270 of Human Hex
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2546630
产品详细信息
Recommended positive controls: K562, THP-1.
Predicted reactivity: Mouse (92%), Rat (94%), Pig (95%), Bovine (94%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
HHEX is a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Expression in specific hematopoietic lineages suggests that this protein may play a role in hematopoietic differentiation. Establishes anterior identity at two levels 1) acts early to enhance canonical WNT-signaling by repressing expression of TLE4 and 2) acts later to inhibit NODAL-signaling by directly targeting NODAL.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Hematopoietically-expressed homeobox protein HHEX; homeobox; Homeobox protein HEX; Homeobox protein PRH; homeobox, hematopoietically expressed; Proline-rich homeodomain protein; proline-rich homeodomain-containing transcription factor
基因别名: HEX; HHEX; HMPH; HOX11L-PEN; PRH; PRHX
UniProt ID: (Human) Q03014
Entrez Gene ID: (Human) 3087
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
chromatin binding
protein binding
transcription factor binding
eukaryotic initiation factor 4E binding
DNA binding, bending
TBP-class protein binding
protein homodimerization activity
sequence-specific DNA binding
transcription regulatory region DNA binding
repressing transcription factor binding
HMG box domain binding
homeodomain transcription factor
negative regulation of transcription from RNA polymerase II promoter
vasculogenesis
in utero embryonic development
myeloid leukocyte differentiation
transcription, DNA-templated
mRNA export from nucleus
Notch signaling pathway
endoderm development
cell proliferation
anterior/posterior pattern specification
negative regulation of transcription by transcription factor localization
negative regulation of transcription by competitive promoter binding
Wnt signaling pathway
negative regulation of angiogenesis
poly(A)+ mRNA export from nucleus
interkinetic nuclear migration
cell differentiation
positive regulation of Wnt signaling pathway
B cell differentiation
thyroid gland development
negative regulation of vascular endothelial growth factor receptor signaling pathway
pancreas development
protein localization to nucleus
embryonic heart tube development
multicellular organism growth
regulation of cell proliferation
negative regulation of cyclin-dependent protein serine/threonine kinase activity
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
forebrain morphogenesis
primary lung bud formation
gall bladder development
hepatic duct development
hepatoblast differentiation
hepatocyte differentiation
DNA conformation change
primitive streak formation
