Invitrogen

Histone H1.4 Polyclonal Antibody

Histone H1.4 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Histone H1.4 Antibody (PA5-31908) in IHC (P)

Immunohistochemical analysis of paraffin-embedded Hela xenograft, using Histone H1.4 (Product # PA5-31908) antibody at 1:500 dilution. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.

Histone H1.4 Antibody in Western Blot (WB)

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产品信息

PA5-31908

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:3,000

查看1篇已发表文章 1篇已发表文章

免疫组化（石蜡） (IHC (P))

1:100-1:1,000

产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide corresponding to a region within amino acids 1 and 69 of Human Histone H1.4

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7, with 1% BSA, 20% glycerol

内含物

0.01% thimerosal

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2549381

产品详细信息

Recommended positive controls: HeLa Nucleus.

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

LINC00842 inactivates transcription co-regulator PGC-1α to promote pancreatic cancer malignancy through metabolic remodelling.

Nature communications

Huang X,Pan L,Zuo Z,Li M,Zeng L,Li R,Ye Y,Zhang J,Wu G,Bai R,Zhuang L,Wei L,Zheng Y,Su J,Deng J,Deng S,Zhang S,Zhu S,Che X,Wang C,Wu C,Chen R,Lin D,Zheng J

PA5-31908 was used in Western Blot to demonstrate that LINC00842 plays a role in promoting PDAC malignancy and thus might serve as a druggable target.

Tue Jun 22 00:00:00 UTC 2021

LINC00842 inactivates transcription co-regulator PGC-1α to promote pancreatic cancer malignancy through metabolic remodelling.

Nature communications

Huang X,Pan L,Zuo Z,Li M,Zeng L,Li R,Ye Y,Zhang J,Wu G,Bai R,Zhuang L,Wei L,Zheng Y,Su J,Deng J,Deng S,Zhang S,Zhu S,Che X,Wang C,Wu C,Chen R,Lin D,Zheng J

PA5-31908 was used in Western Blot to demonstrate that LINC00842 plays a role in promoting PDAC malignancy and thus might serve as a druggable target.