Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
产品信息
MA5-35819
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
ARC1656
抗原
A synthetic peptide corresponding to a sequence within amino acids 524-623 of human hnRNP Q/SYNCRIP (O60506)
偶联物
形式
Liquid
浓度
1.2 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2849719
产品详细信息
Immunogen sequence: SQRGGPGSAR GVRGARGGAQ QQRGRGVRGA RGGRGGNVGG KRKADGYNQP DSKRRQTNNQ NWGSQPIAQQ PLQGGDHSGN YGYKSENQEF YQDTFGQQWK
靶标信息
Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation; seems not to be essential for GAIT complex function.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: Glycine- and tyrosine-rich RNA-binding protein; GRY-RBP; Heterogeneous nuclear ribonucleoprotein Q; hnRNP; hnRNP Q; hnRNP-Q; Liver regeneration-related protein LRRG077; NS1-associated protein 1; pp68; RRM RNA binding protein GRY-RBP; synaptotagmin binding, cytoplasmic RNA interacting protein; Synaptotagmin-binding, cytoplasmic RNA-interacting protein
基因别名: 2610109K23Rik; 4632417O19Rik; Ab2-339; GRY-RBP; GRYRBP; hnRNP-Q; HNRNPQ; HNRPQ; HNRPQ1; NSAP1; Nsap1l; PP68; SYNCRIP
UniProt ID: (Human) O60506, (Rat) Q7TP47, (Mouse) Q7TMK9
Entrez Gene ID: (Human) 10492, (Rat) 363113, (Mouse) 56403
mRNA splicing, via spliceosome
osteoblast differentiation
RNA processing
circadian rhythm
RNA splicing
viral process
negative regulation of translation
positive regulation of translation
CRD-mediated mRNA stabilization
cellular response to interferon-gamma
negative regulation of mRNA modification
mRNA processing
