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产品信息
PA5-72855
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
HOPX antibody for a 16 amino acid peptide near the amino terminus of human HOPX. The immunogen is within the first 50 amino acids of HOPX.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2718709
靶标信息
HOPX is an atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. HOPX acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. HOPX prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. HOPX overexpression causes cardiac hypertrophy and may act as a tumor suppressor.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Homeodomain-only protein; Lung cancer-associated Y protein; not expressed in choriocarcinoma clone 1; Not expressed in choriocarcinoma protein 1; Odd homeobox protein 1
基因别名: CAMEO; HOD; HOP; HOPX; LAGY; NECC1; OB1; SMAP31; TOTO
UniProt ID: (Human) Q9BPY8
Entrez Gene ID: (Human) 84525
negative regulation of transcription from RNA polymerase II promoter
trophectodermal cell differentiation
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
heart development
regulation of heart contraction
histone deacetylation
regulation of protein binding
positive regulation of skeletal muscle tissue regeneration
negative regulation of cell differentiation
lung alveolus development
positive regulation of striated muscle cell differentiation
