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HuD Antibody (PA5-116521) in IHC (P)
Immunohistochemistry analysis of HuD in paraffin-embedded mouse brain. Samples were incubated with HuD Polyclonal antibody (Product # PA5-116521) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
产品信息
PA5-116521
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ELAVL4 (NP_0687712)
偶联物
形式
Liquid
浓度
1.25 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2901152
产品详细信息
Positive Samples: Mouse brain, Rat brain
Immunogen sequence: MVMIISTMEP QVSNGPTSNT SNGPSSNNRN CPSPMQTGAT TDDSKTNLIV NYLPQNMTQE EFRSLFGSIG EIESCKLVRD KITGQSLGYG FVNYIDPKDA
靶标信息
HuD, otherwise known as ELAV-like protein 4 or PNEM, is a protein that in humans is encoded by the ELAVL4 gene. This human gene is located at 1p34 by in situ hybridization. The HuD/ELAVL4 protein is an RNA-binding protein. ELAVL4 has specificity for 3-prime uridylate-rich untranslated regions of growth factor mRNAs. HuD is expressed only in neurons and it binds to AU-rich element-containing mRNAs. As a result of this interaction the, half-life of the transcript is increased. Additionally, HuD is important in neurons during brain development and plasticity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D); ELAV-like protein 4; HU-antigen D; HuD; Paraneoplastic encephalomyelitis antigen HuD; RNA-binding protein HUD3
基因别名: Elav; Elavl4; HuD; PNEM; r-HuD; RGD1561943
UniProt ID: (Mouse) Q61701, (Rat) O09032
Entrez Gene ID: (Mouse) 15572, (Rat) 432358
learning
locomotory behavior
neuron differentiation
regulation of mRNA stability
dendrite morphogenesis
positive regulation of dendrite development
nervous system development
aging
associative learning
regeneration
response to endoplasmic reticulum stress
response to cocaine
cellular response to nerve growth factor stimulus
