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产品信息
PA5-89402
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 35-170 of human IDH3B (NP_0088302)
偶联物
形式
Liquid
浓度
1.08 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2805548
产品详细信息
Immunogen sequence: ASRSQAEDVR VEGSFPVTML PGDGVGPELM HAVKEVFKAA AVPVEFQEHH LSEVQNMASE EKLEQVLSSM KENKVAIIGK IHTPMEYKGE LASYDMRLRR KLDLFANVVH VKSLPGYMTR HNNLDLVIIR EQTEGE; Positive Samples: H460, HeLa, 293T, Mouse kidney, Mouse heart, Mouse lung, Rat kidney, Rat heart, Rat lung; Cellular Location: Mitochondrion
靶标信息
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the beta subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DH3B; H-IDHB; H-IDHG; isocitrate dehydrogenase 3 (NAD+) beta; isocitrate dehydrogenase 3 beta; Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial; Isocitric dehydrogenase subunit beta; N14A tumor-related protein; NAD(+)-specific ICDH subunit beta; NAD+-specific isocitrate dehydrogenase b subunit
基因别名: C78231; IDH3B; RP46
UniProt ID: (Human) O43837, (Rat) Q68FX0
Entrez Gene ID: (Human) 3420, (Rat) 94173, (Mouse) 170718
