Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
产品信息
169355-MSM1-P1
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG, kappa
分类
Monoclonal
类型
Antibody
克隆号
IDO2/2638
抗原
Recombinant fragment (around aa 200-350) of human IDO2 protein.
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
Protein A/G
保存液
PBS with 0.05% BSA
内含物
0.05% sodium azide
保存条件
4° C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Antibody is stable for 24 months.
Positive Control: Human placenta or liver. Cellular Localization: Cytoplasm
Specificity Comments: IDO2 is a presumptive immunomodulatory gene based on its close structural relationship to IDO1 and its expression in a variety of antigen-presenting cell types. Both IDO1 and IDO2 will catabolize tryptophan to kynurenine. Biochemical studies indicate that both enzymes are similarly robust in catabolic activity, although the in vitro conditions required for IDO2 to manifest the same level of activity differ somewhat from IDO1. However, whether IDO2 is active as a tryptophan catabolizing enzyme in human dendritic cells has been disputed. Further work is needed to conclusively determine that IDO1 and IDO2 are similar in their preference for substrates and reaction pathways to generate product. A non-redundant function for IDO2 relative to IDO1 is suggested by their rather distinct expression patterns and response to extracellular stimuli.
靶标信息
Along with the enzymes encoded by the INDO and TDO2 genes, the enzyme encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: 3-dioxygenase 2; 3-dioxygenase-like protein 1; EC 1.13.11.; IDO-2; INDOL 1; indoleamine 2; Indoleamine 2,3 dioxygenase 2; Indoleamine 2,3 dioxygenase like 1 protein; Indoleamine 2,3-dioxygenase 2; indoleamine 2,3-dioxygenase-like 1 protein; Indoleamine 2,3-dioxygenase-like protein 1; Indoleamine pyrrole 2,3 dioxygenase like 1; Indoleamine-pyrrole 2; indoleamine-pyrrole 2,3 dioxygenase-like 1; Indoleamine-pyrrole 2,3-dioxygenase-like protein 1
基因别名: IDO2; INDOL1
UniProt ID: (Human) Q6ZQW0
Entrez Gene ID: (Human) 169355
