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IFITM1 Antibody (PA5-92168) in IHC (P)
Immunohistochemistry analysis of IFITM1 in paraffin-embedded mouse kidney. Samples were incubated with IFITM1 Polyclonal antibody (Product # PA5-92168) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
产品信息
PA5-92168
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence within amino acids 50-125 of human CD225/IFITM1 (NP_0036323)
偶联物
形式
Liquid
浓度
2.26 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2806398
产品详细信息
Immunogen sequence: CCLGFIAFAY SVKSRDRKMV GDVTGAQAYA STAKCLNIWA LILGILMTIG FILLLVFGSV TVYHIMLQII QEKRGY; Positive Samples: K-562; Cellular Location: Cell membrane, Single-pass membrane protein
靶标信息
IFITM1 (Interferon inducible transmembrane protein 1) is a member of the IFN-inducible transmembrane protein family. It is an essential mediator of interferon-gamma-induced antiproliferation and plays a role in the control of cell growth. IFITM1 is upregulated in several tumor types and may be useful as a tumor biomarker. Both mouse IFITM1 and IFITM3 are expressed on the cell surfaces of primordial germ cells in a developmentally-regulated manner. IFITM1 activity is required for primordial germ cell transit, and IFITM1 acts as a repulsive molecule by repelling non-IFITM1-expressing primordial germ cells from the mesoderm into the endoderm.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 27-Sep; CD225; Dispanin subfamily A member 2a; DSPA2a; Fragilis protein 2; fragilis2; ifitm-like protein 2; interferon induced transmembrane protein 2 like; Interferon-induced protein 17; Interferon-induced transmembrane protein 1; Interferon-inducible protein 9-27; Leu-13 antigen; Mil-2; Mouse ifitm-like protein 2
基因别名: 1110036C17Rik; 9-27; CD225; DSPA2a; IFI17; IFITM1; LEU13; Mil-2; Mil2
UniProt ID: (Human) P13164, (Mouse) Q9D103
Entrez Gene ID: (Human) 8519, (Mouse) 68713
ossification
cell surface receptor signaling pathway
negative regulation of cell proliferation
response to virus
negative regulation of cell migration
response to interferon-gamma
response to interferon-alpha
response to interferon-beta
negative regulation of viral genome replication
positive regulation of osteoblast differentiation
negative regulation of viral entry into host cell
regulation of immune response
defense response to virus
type I interferon signaling pathway
somitogenesis
immune system process
response to biotic stimulus
anterior/posterior pattern specification
innate immune response
