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Invitrogen
IFN beta Monoclonal Antibody (A1 (IFNb)), Functional Grade, eBioscience™
产品信息
16-9978-81
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
A1 (IFNb)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.2
内含物
no preservative
保存条件
4° C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_1210676
产品详细信息
Description: The A1 monoclonal antibody reacts with human IFN-beta. The A1 antibody is a neutralizing antibody. IFN-beta is classified as a type I IFN which is a group of structurally and functionally related proteins demonstrating anti-viral, anti-parasitic, and anti-proliferative activities.
Applications Reported: The A1 antibody has been reported for use in cytokine neutralization.
Applications Tested: The Functional Grade Purified A1 antibody has been tested in bioassay for neutralization of IFN-beta bioactivity.
The A1 antibody at 3-6 µg/mL has been found to inhibit by 50% the biological effects of 50 pg/mL human IFN-beta (ND50), in an EMCV assay of A549 cell protection. Detailed information and protocols about cytokine bioassays and in vitro cytokine neutralization using antibodies can be found in the Best Protocols® section.
Storage and handling: Use in a sterile environment.
Filtration: 0.2 µm post-manufacturing filtered.
Purity: Greater than 90%, as determined by SDS-PAGE.
Endotoxin Level: Less than 0.001 ng/µg antibody, as determined by LAL assay.
Aggregation: Less than 10%, as determined by HPLC.
靶标信息
Type I Interferons (IFN-alpha/beta) are produced primarily in response to viral infection by Natural IFN-producing cells (IPCs) as part of the host immune response. IFNs can also inhibit the development of tumors. IFN-beta binding results in the activation of the tyrosine kinases Jak1 and Tyk2, phosphorylation of members of the STAT family of transcription factors, and the transcription and expression of the immune response genes. More recently, several members of the toll-like receptor (TLR) family were found to stimulate the production IFN-beta. IFN-beta is currently used clinically for treatment of tumors, infections and multiple sclerosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Fibroblast interferon; IFN b; IFN β; IFN-beta; IFNbeta; IFNβ; Interferon; Interferon b; Interferon beta; interferon, beta 1, fibroblast; interferon-beta; RP11-113D19.1
基因别名: IFB; IFF; IFN-beta; IFNB; IFNB1
UniProt ID: (Human) P01574
Entrez Gene ID: (Human) 3456
adaptive immune response
T cell activation involved in immune response
B cell activation involved in immune response
natural killer cell activation involved in immune response
humoral immune response
cell surface receptor signaling pathway
blood coagulation
response to virus
natural killer cell activation
B cell differentiation
positive regulation of peptidyl-serine phosphorylation of STAT protein
cellular response to interferon-beta
B cell proliferation
defense response to bacterium
response to exogenous dsRNA
negative regulation of viral genome replication
positive regulation of innate immune response
regulation of MHC class I biosynthetic process
negative regulation of T cell differentiation
positive regulation of transcription from RNA polymerase II promoter
defense response to virus
type I interferon signaling pathway
regulation of type I interferon-mediated signaling pathway
cellular response to exogenous dsRNA
cellular response to dexamethasone stimulus
cellular response to virus
negative regulation of T-helper 2 cell cytokine production
positive regulation of apoptotic signaling pathway
