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产品信息
PA5-31381
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Zebrafish
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein fragment corresponding to a region within amino acids 667 and 883 of Human IFT122
偶联物
形式
Liquid
浓度
0.95 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2548855
产品详细信息
Recommended positive controls: 293T.
Predicted reactivity: Mouse (84%), Rat (84%), Bovine (87%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This cytoplasmic protein contains seven WD repeats and an AF-2 domain which function by recruiting coregulatory molecules and in transcriptional activation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: intraflagellar transport 122 homolog; Intraflagellar transport protein 122 homolog; WD repeat domain 10; WD repeat-containing protein 10; WD repeat-containing protein 140
基因别名: CED; CED1; IFT122; SPG; WDR10; WDR10p; WDR140; zgc:77217
UniProt ID: (Human) Q9HBG6, (Zebrafish) Q6NYH1
Entrez Gene ID: (Human) 55764, (Zebrafish) 405826
mesonephros development
multicellular organism development
heart development
regulation of smoothened signaling pathway
photoreceptor cell morphogenesis
cell projection organization
melanosome transport
intraciliary retrograde transport
opsin transport
intraciliary transport
photoreceptor cell maintenance
negative regulation of smoothened signaling pathway
camera-type eye morphogenesis
cilium morphogenesis
protein localization to cilium
non-motile cilium assembly
neural tube closure
signal transduction downstream of smoothened
embryonic body morphogenesis
negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning
embryonic heart tube development
embryonic forelimb morphogenesis
intraciliary anterograde transport
intraciliary transport involved in cilium morphogenesis
cilium assembly
embryonic digit morphogenesis
negative regulation of epithelial cell proliferation
limb development
ciliary receptor clustering involved in smoothened signaling pathway
smoothened signaling pathway involved in dorsal/ventral neural tube patterning
embryonic heart tube left/right pattern formation
establishment of protein localization to organelle
