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产品信息
PA5-116914
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 22-258 of human IGFBP4 (NP_0015432)
偶联物
形式
Liquid
浓度
1.68 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2901544
产品详细信息
Positive Samples: A-549, SW480
Immunogen sequence: DEAIHCPPCS EEKLARCRPP VGCEELVREP GCGCCATCAL GLGMPCGVYT PRCGSGLRCY PPRGVEKPLH TLMHGQGVCM ELAEIEAIQE SLQPSDKDEG DHPNNSFSPC SAHDRRCLQK HFAKIRDRST SGGKMKVNGA PREDARPVPQ GSCQSELHRA LERLAASQSR THEDLYIIPI PNCDRNGNFH PKQCHPALDG QRGKCWCVDR KTGVKLPGGL EPKGELDCHQ LADSFRE
靶标信息
This gene is a member of the insulin-like growth factor binding protein family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.
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生物信息学
蛋白别名: Band 3A; differentially expressed in B16F10 2; IBP-4; IGF-binding protein 4; IGFBP; IGFBP-4; Insulin like growth factor binding protein; insulin-like growth factor binding protein 4; Insulin-like growth factor-binding protein 4
基因别名: AI875747; BP-4; Deb2; HT29-IGFBP; IBP4; IGF-BP4; IGFBP-4; IGFBP4
UniProt ID: (Human) P22692, (Mouse) P47879, (Rat) P21744
Entrez Gene ID: (Human) 3487, (Mouse) 16010, (Rat) 360622
skeletal system development
regulation of cell growth
DNA metabolic process
inflammatory response
signal transduction
cell proliferation
regulation of glucose metabolic process
positive regulation of MAPK cascade
regulation of insulin-like growth factor receptor signaling pathway
positive regulation of insulin-like growth factor receptor signaling pathway
cellular protein metabolic process
type B pancreatic cell proliferation
negative regulation of canonical Wnt signaling pathway
regulation of growth
intracellular signal transduction
