Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
图: 1 / 5
IGHMBP2 Antibody (PA5-116653) in IHC (P)
Immunohistochemistry analysis of IGHMBP2 in paraffin-embedded human mammary cancer. Samples were incubated with IGHMBP2 Polyclonal antibody (Product # PA5-116653) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
产品信息
PA5-116653
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 540-720 of human IGHMBP2 (NP_0021712)
偶联物
形式
Liquid
浓度
2.07 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2901284
产品详细信息
Positive Samples: HepG2, A-549, Mouse brain, Mouse testis, Rat brain
Immunogen sequence: PYNLQVDLLR QSLVHRHPEL EIKSVDGFQG REKEAVILSF VRSNRKGEVG FLAEDRRINV AVTRARRHVA VICDSRTVNN HAFLKTLVEY FTQHGEVRTA FEYLDDIVPE NYSHENSQGS SHAATKPQGP ATSTRTGSQR QEGGQEAAAP ARQGRKKPAG KSLASEAPSQ PSLNGGSPEG V
靶标信息
5' to 3' helicase that unwinds RNA and DNA duplices in an ATP-dependent reaction. Acts as a transcription regulator. Required for the transcriptional activation of the flounder liver-type antifreeze protein gene. Exhibits strong binding specificity to the enhancer element B of the flounder antifreeze protein gene intron. Binds to the insulin II gene RIPE3B enhancer region. May be involved in translation. DNA-binding protein specific to 5'-phosphorylated single-stranded guanine-rich sequence related to the immunoglobulin mu chain switch region. Preferentially binds to the 5'-GGGCT-3' motif. Interacts with tRNA-Tyr. Stimulates the transcription of the human neurotropic virus JCV.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: AEP; antifreeze enhancer-binding protein; Antifreeze enhancer-binding protein ortholog; ATP-dependent helicase IGHMBP2; cardiac transcription factor 1; DNA-binding protein SMUBP-2; GF-1; Glial factor 1; Immunoglobulin mu-binding protein 2; immunoglobulin S mu binding protein 2; neuromuscular degeneration; p110 subunit; zinc finger, AN1-type domain 7
基因别名: AEP; CATF1; CMT2S; HCSA; HMN6; IGHMBP2; nmd; RIPE3b1; sma; SMARD1; Smbp-2; SMBP2; SMUBP2; ZFAND7
UniProt ID: (Human) P38935, (Rat) Q9EQN5
Entrez Gene ID: (Human) 3508, (Mouse) 20589, (Rat) 29532
tRNA binding
DNA binding
DNA helicase activity
single-stranded DNA binding
RNA binding
protein binding
ATP binding
DNA-dependent ATPase activity
transcription factor binding
RNA-dependent ATPase activity
zinc ion binding
ATP-dependent 5'-3' RNA helicase activity
ribosome binding
ATP-dependent 5'-3' DNA helicase activity
nucleotide binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
nucleic acid binding
helicase activity
hydrolase activity
metal ion binding
protein self-association
DNA metabolism protein
DNA replication
DNA repair
DNA recombination
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
translation
DNA duplex unwinding
protein homooligomerization
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
spinal cord motor neuron differentiation
metabolic process
