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产品信息
MA5-15648
产品规格
种属反应
Fruit fly,
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
3G8
抗原
Purified recombinant fragment of human IHOG expressed in E. Coli.
偶联物
形式
Liquid
浓度
Conc. Not Determined
保存液
ascites
内含物
0.03% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_10982020
产品详细信息
MA5-15648 targets IHOG in indirect ELISA, WB applications and shows reactivity with Drosophila samples.
The MA5-15648 immunogen is purified recombinant fragment of human IHOG expressed in E. Coli.
MA5-15648 detects IHOG which has a predicted molecular weight of approximately 98kDa.
靶标信息
The ihog gene (interference hedgehog), identified by RNA interference in Drosophila cultured cells, encodes a type 1 membrane protein shown here to bind and to mediate response to the active Hedgehog (Hh) protein signal. ihog mutations produce defects characteristic of Hh signaling loss in embryos and imaginal discs, and epistasis analysis places ihog action at or upstream of the negatively acting receptor component, Patched (Ptc). The first of two extracellular fibronectin type III (FNIII) domains of the Ihog protein mediates a specific interaction with Hh protein in vitro, but the second FNIII domain is additionally required for in vivo signaling activity and for Ihog-enhanced binding of Hh protein to cells coexpressing Ptc. Other members of the Ihog family, including Drosophila Boi and mammalian CDO and BOC, also interact with Hh ligands via a specific FNIII domain, thus identifying an evolutionarily conserved family of membrane proteins that function in Hh signal response.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CG9211-PA; Dmel ihog; ihog-PA; Interference hedgehog
基因别名: CG9211; CT26314; Dmel\CG9211; Dmel_CG9211; Ihog
UniProt ID: (Fruit fly) Q9VM64
Entrez Gene ID: (Fruit fly) 33972
