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IKK epsilon Antibody (PA5-29294) in ICC/IF
IKBKE antibody [C2C3], C-term detects IKBKE protein at cytoplasm and nucleus by immunofluorescent analysis. Sample: HeLa cells were fixed in 4% paraformaldehyde for 10 min. Green: IKBKE protein stained by IKBKE antibody [C2C3], C-term (Product # PA5-29294) diluted at 1:100. Blue: Hoechst 33342 staining. Scale bar = 10 µm.
产品信息
PA5-29294
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 494 and 710 of Human IKBKE
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 10% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2546770
产品详细信息
Recommended positive controls: 293T.
Predicted reactivity: Bovine (86%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
IKBKE is an activator of nuclear factor-kappa-B. Over expression of IKBKE has been observed in breast cancer cells, and suppression of IKBKE induces cell death. NF-kappa-B is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kappa-B mediates the expression of a great variety of genes in response to extracellular stimuli. NF-kappa-B is associated with Ikappa-B proteins in the cell cytoplasm, which inhibit NF-kappa-B activity. Ikappa-B is phosphorylated by Ikappa-B kinase (IKK) complex that contains IKK-a, IKK-b, and IKK-gamma. A novel molecule in the IKK complex was recently identified and designated IKK-iota/IKK-i. IKK epsilon is required for the activation of NF-kappa-B by PMA and T cell receptors but not by TNF-a and IL-1. IKK-iota/IKK-i message is expressed in a variety of tissues and is inducible by TNF-a, IL-1, and LPS.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: I-kappa-B kinase epsilon; IKK-epsilon; IKK-i; IKK-related kinase epsilon; Inducible I kappa-B kinase; inducible IkappaB kinase; Inhibitor of nuclear factor kappa-B kinase subunit epsilon; RP11-534L20.1
基因别名: IKBKE; IKK-E; IKK-i; IKKE; IKKI; KIAA0151
UniProt ID: (Human) Q14164
Entrez Gene ID: (Human) 9641
protein phosphorylation
immune response
I-kappaB phosphorylation
intrinsic apoptotic signaling pathway in response to DNA damage
negative regulation of type I interferon production
response to type I interferon
response to interferon-beta
TRIF-dependent toll-like receptor signaling pathway
NIK/NF-kappaB signaling
positive regulation of I-kappaB kinase/NF-kappaB signaling
protein homooligomerization
cellular response to virus
