Invitrogen

IKK epsilon Polyclonal Antibody

IKK epsilon Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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IKK epsilon Antibody (PA5-87387) in IHC (P)

Immunohistochemistry analysis of IKK epsilon in paraffin-embedded human colon carcinoma. Samples were incubated with IKK epsilon Polyclonal antibody (Product # PA5-87387) using a dilution of 1:200 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.

IKK epsilon Antibody in Western Blot (WB)

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产品信息

PA5-87387

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

免疫组化（石蜡） (IHC (P))

1:50-1:200

免疫细胞化学 (ICC/IF)

1:50-1:200

酶联免疫吸附实验 (ELISA)

1 µg/mL

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant fusion protein containing a sequence corresponding to amino acids 497-716 of human IKK? (NP_0547211)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.58 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.01% thimerosal

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

AB_2804110

产品详细信息

Positive Samples: SW480, DU145, MCF7, Mouse liver; Cellular Location: Cytoplasm, Nucleus, PML body

Immunogen sequence: SRLRTLAEVL SRCSQNITET QESLSSLNRE LVKSRDQVHE DRSIQQIQCC LDKMNFIYKQ FKKSRMRPGL GYNEEQIHKL DKVNFSHLAK RLLQVFQEEC VQKYQASLVT HGKRMRVVHE TRNHLRLVGC SVAACNTEAQ GVQESLSKLL EELSHQLLQD RAKGAQASPP PIAPYPSPTR KDLLLHMQEL CEGMKLLASD LLDNNRIIER LNRVPAPPDV

靶标信息

IKBKE is an activator of nuclear factor-kappa-B. Over expression of IKBKE has been observed in breast cancer cells, and suppression of IKBKE induces cell death. NF-kappa-B is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kappa-B mediates the expression of a great variety of genes in response to extracellular stimuli. NF-kappa-B is associated with Ikappa-B proteins in the cell cytoplasm, which inhibit NF-kappa-B activity. Ikappa-B is phosphorylated by Ikappa-B kinase (IKK) complex that contains IKK-a, IKK-b, and IKK-gamma. A novel molecule in the IKK complex was recently identified and designated IKK-iota/IKK-i. IKK epsilon is required for the activation of NF-kappa-B by PMA and T cell receptors but not by TNF-a and IL-1. IKK-iota/IKK-i message is expressed in a variety of tissues and is inducible by TNF-a, IL-1, and LPS.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: I-kappa-B kinase epsilon; IKK-E; IKK-epsilon; IKK-i; IKK-related kinase epsilon; Inducible I kappa-B kinase; inducible IKappaB kinase; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon; inhibitor of kappaB kinase epsilon; Inhibitor of nuclear factor kappa-B kinase subunit epsilon; RP11-534L20.1

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基因别名: AW558201; IKBKE; IKK-E; IKK-i; IKKE; IKKepsilon; IKKI; KIAA0151

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UniProt ID: (Human) Q14164, (Mouse) Q9R0T8

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Entrez Gene ID: (Human) 9641, (Rat) 363984, (Mouse) 56489

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功能