Invitrogen

IL-10 Monoclonal Antibody (945A1A926C2), Biotin

产品信息

ASC9109

应用

建议稀释比

已发表文章

流式细胞分析 (Flow)

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酶联免疫吸附实验 (ELISA)

Assay-dependent

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Luminex (LUM)

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亲和纯化 (AP)

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其他PubMed (Misc)

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产品规格

种属反应

Pig

已发表种属

Pig

宿主/亚型

Mouse / IgG1, kappa

分类

Monoclonal

类型

Antibody

克隆号

945A1A926C2

抗原

Recombinant swine IL-10.

偶联物

Biotin Biotin Biotin

形式

Liquid

浓度

0.5 mg/mL

纯化类型

purified

保存液

PBS, pH 7.2

内含物

0.1% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

AB_2536428

靶标信息

IL-10 encodes a protein that acts as a cytokine and is primarily produced by monocytes, with some production by lymphocytes. This cytokine has various effects on immunoregulation and inflammation, including down-regulating the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. Additionally, IL-10 can block NF-kappa B activity and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice have suggested that this cytokine is an essential immunoregulator in the intestinal tract. Mutations in this gene have been associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. Diseases associated with IL10 include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

A Porcine Model of Zika Virus Infection to Profile the In Utero Interferon Alpha Response.

Methods in molecular biology (Clifton, N.J.)

Trus I,Walker S,Fuchs M,Udenze D,Gerdts V,Karniychuk U

ASC9109 was used in Biosensors to demonstrate altered IFN-α responses in porcine offspring affected with subclinical in utero ZIKV infection.

Wed Mar 10 00:00:00 UTC 2021

Heterologous challenge in the presence of maternally-derived antibodies results in vaccine-associated enhanced respiratory disease in weaned piglets.

Virology

Rajao DS,Sandbulte MR,Gauger PC,Kitikoon P,Platt R,Roth JA,Perez DR,Loving CL,Vincent AL

ASC9109 was used in flow cytometry to study the result of vaccine-associated enhanced respiratory disease in weaned piglets due to heterologous challenge in the presence of maternally-derived antibodies

Fri Apr 01 00:00:00 UTC 2016

Oral antigen exposure in newborn piglets circumvents induction of oral tolerance in response to intraperitoneal vaccination in later life.

BMC veterinary research

Pasternak JA,Ng SH,Buchanan RM,Mertins S,Mutwiri GK,Gerdts V,Wilson HL

ASC9109 was used in a Luminex assay to investigate whether oral antigen exposure in newborn piglets circumvents induction of oral tolerance in response to intraperitoneal vaccination in later life.

Sat Mar 07 00:00:00 UTC 2015

Development of a bead-based multiplex assay for the simultaneous detection of porcine inflammation markers using xMAP technology.

Cytometry. Part A : the journal of the International Society for Analytical Cytology

Bongoni AK,Lanz J,Rieben R,Banz Y

ASC9109 was used in Luminex to simultaneously detect porcine cytokines [interleukin (IL)-1β, IL-6, IL-10, and tumor necrosis factor alpha], chemokines (IL-8 and monocyte chemotactic protein 1), growth factors [basic fibroblast growth factor (bFGF), vascular endothelial growth factor, and platelet-derived growth factor-bb], and injury markers (cardiac troponin-I) as well as complement activation markers (C5a and sC5b-9).

Mon Jul 01 00:00:00 UTC 2013

Comparison of humoral and cellular immune responses to inactivated swine influenza virus vaccine in weaned pigs.

Veterinary immunology and immunopathology

Platt R,Vincent AL,Gauger PC,Loving CL,Zanella EL,Lager KM,Kehrli ME,Kimura K,Roth JA

ASC9109 was used in flow cytometry to compare humoral and cellular immune responses to inactivated swine influenza virus vaccine using pigs.

Mon Aug 15 00:00:00 UTC 2011

Porcine circovirus type 2 (PCV2) Cap and Rep proteins are involved in the development of cell-mediated immunity upon PCV2 infection.

Veterinary immunology and immunopathology

Fort M,Sibila M,Nofrarías M,Pérez-Martín E,Olvera A,Mateu E,Segalés J

ASC9109 was used in ELISA to assess the role of the capside, replicase, and Porcine circovirus type 2 in the induction of cell-mediated immunity upon infection

Fri Oct 15 00:00:00 UTC 2010

Characterization of conventional and plasmacytoid dendritic cells in swine secondary lymphoid organs and blood.

Veterinary immunology and immunopathology

Jamin A,Gorin S,Le Potier MF,Kuntz-Simon G

ASC9109 was used in flow cytometry to characterize porcine dendritic cells from secondary lymphoid organs

Fri Dec 15 00:00:00 UTC 2006

Immune response characteristics following emergency vaccination of pigs against foot-and-mouth disease.

Vaccine

Barnard AL,Arriens A,Cox S,Barnett P,Kristensen B,Summerfield A,McCullough KC

ASC9109 was used in ELISA to study pigs vaccinated with the emergency inactivated foot-and-mouth disease virus vaccine.

Tue Jan 11 00:00:00 UTC 2005

生物信息学

蛋白别名: CSIF; Cytokine synthesis inhibitory factor; H-IL-10; il 10; IL-10; ILN; Interleukin; Interleukin-10; Interleukin10; MGC126450; MGC126451; RP11-262N9.1

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基因别名: CSIF; IL-10; IL10

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UniProt ID: (Pig) Q29055

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Entrez Gene ID: (Pig) 397106

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功能

cytokine activity protein dimerization activity

参与通路